Boron deficiency disables Xenopus laevis oocyte maturation events

Biological Trace Element Research
Douglas J Fort

Abstract

Processes of oocyte maturation that may be affected by boron (B) deficiency were studied to potentially determine a possible biochemical role of B in the Xenopus laevis oocyte. More specifically, the Xenopus oocyte membrane progesterone receptor (OMPR) in B-deficient oocytes was characterized by evaluating progesterone affinity for the OMPR and OMPR responsiveness to progesterone stimulation. The responsiveness of B-deficient oocytes to microinjection of a purified oocyte cytoplasmic fraction (OCF) from B-adequate oocytes was also studied to evaluate which aspects of the maturation process were affected by B deficiency. Results suggested that B deficiency resulted in incomplete oocyte maturation and that maturation could not be induced by the administration of exogenous progesterone. Progesterone successfully induced germinal vesicle breakdown (GVBD) in oocytes from females fed a B-supplemented diet (+ B) and females administered a traditional diet of beef liver and lung (B adequate). Addition of exogenous B to the -B oocytes increased the rate of progesterone-induced GVBD slightly. The B-deficient X. laevis oocytes were capable of undergoing GVBD when endogenously stimulated by microinjected purified B-adequate OCF. These resu...Continue Reading

Citations

Jul 27, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Forrest H Nielsen
Mar 28, 2008·Nutrition Reviews·Forrest H Nielsen
Jun 21, 2011·Plant Science : an International Journal of Experimental Plant Biology·Juan J Camacho-CristóbalAgustín González-Fontes
Oct 27, 2004·Cancer Letters·Wade T Barranco, Curtis D Eckhert
Jun 23, 2016·Toxicology Letters·E D Farfán-GarcíaM A Soriano-Ursúa
Oct 28, 2019·Biological Trace Element Research·Liangyue LuShenghe Li
Mar 17, 2018·Biological Trace Element Research·Haseeb KhaliqPeng Ke-Mei

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