Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Olcay BoyaciogluMehmet Korkmaz

Abstract

The relationship between daily boron intake and osteocalcin-mediated osteoporosis was studied in boron-exposed postmenopausal women. It is known that boron and osteocalcin are important in bone metabolism, however the effect of boron in bone metabolism has not been fully discovered. The study was performed on 53 postmenopausal women aged 55-60 living in parts of Balikesir, Turkey, where the subjects are naturally exposed to high (≥1 mg/L) or low (<1 mg/L) boron concentration in drinking water. 24-h urine samples were collected from all participants and creatinine clearance was detected. Boron intake levels of the subjects whose clearance levels were between 80-124 mL/min were measured by inductively coupled plasma-optical emission spectrometry (ICP-OES) in urine samples. Serum osteocalcin levels of the subjects were measured by osteocalcin enzyme-linked immunosorbent assay (ELISA) kit. Osteocalcin polymorphism rs1800247 was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Serum osteocalcin levels in boron-exposed postmenopausal women were significantly higher than that of control group (P ≤ 0.05) and the correlation between the serum osteocalcin level and rs1800247 polymorphis...Continue Reading

Citations

Nov 24, 2018·Biological Trace Element Research·Erin Gaffney-Stomberg
May 10, 2019·Biological Trace Element Research·Merve GizerPetek Korkusuz
Jun 12, 2020·Biological Trace Element Research·Ahmet Engin PazarçevirenZafer Evis
Mar 15, 2021·Biological Trace Element Research·Eda Çiftci DedeFeza Korkusuz

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