PMID: 9555163Apr 29, 1998Paper

Boron neutron capture a a new radiotherapy model

Orvosi hetilap
K HideghétyH Sack

Abstract

The boron neutron capture therapy is based on the reaction occurring with certain probability, if a thermal neutron meets the boron 10 isotope. The low energy slow neutron is captured by the nucleus and it disintegrates into Li-nucleus and He-nucleus (alpha particle). If this physical reaction occurs in a living cell that will be destroyed. If the boron neutron capture reaction could be achieved selectively in malignant cells of tumor patients, that could be an effective therapeutical modality to treat the locally growing cancers. For boron neutron capture therapy to be successful two basic conditions must be fulfilled, an appropriate neutron source must be available and the sufficient number of 10B must be delivered possibly selectively into the tumor cells by a boron compound. At present both part of this binary system are under intensive investigation, the development of the neutron source, the synthetisation and experimental testing of boron delivery agents. The development of the dosimetry, microdosimetry, the work out of the powerful tools of detection the cellular, subcellular 10B distribution, the continuous improvement of the planning system and the optimization of the boron neutron capture therapy are the main point o...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.