Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Tooru AndohHideki Ichikawa

Abstract

Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-L-phenylalanine (L-BPA). Biodistribution data revealed tumor-selective accumulation of (10)B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

References

Oct 24, 2006·International Journal of Radiation Oncology, Biology, Physics·Minoru SuzukiKoji Ono
Jul 26, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Minoru SuzukiKoji Ono
Mar 1, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T FujimotoH Ichikawa
Mar 4, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T AndohH Ichikawa
Jan 7, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Tooru AndohHideki Ichikawa
Sep 2, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Rubén O FaríasSara J González
Mar 17, 2015·Seminars in Radiation Oncology·Feng-Ming Spring Kong, Shulian Wang

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Citations

Jan 3, 2019·International Journal of Radiation Biology·Verónica Andrea TrivillinAmanda E Schwint
Jul 15, 2020·Cells·María Auxiliadora Olivares-UrbanoMaría Isabel Núñez
May 8, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Diego AlbertiSimonetta Geninatti Crich

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