Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer

International Journal of Radiation Oncology, Biology, Physics
Aaro HaapaniemiHeikki Joensuu

Abstract

To investigate the safety and efficacy of boron neutron capture therapy (BNCT) as a larynx-preserving treatment option for patients with recurrent laryngeal cancer. Six patients with locally recurrent squamous cell laryngeal carcinoma and 3 patients with persistent laryngeal cancer after prior treatment were treated with BNCT at the FiR1 facility (Espoo, Finland) in 2006 to 2012. The patients had received prior radiation therapy with or without concomitant chemotherapy to a cumulative median dose of 66 Gy. The median tumor diameter was 2.9 cm (range, 1.4-10.9 cm) before BNCT. Boron neutron capture therapy was offered on a compassionate basis to patients who either refused laryngectomy (n=7) or had an inoperable tumor (n=2). Boronophenylalanine-fructose (400 mg/kg) was used as the boron carrier and was infused over 2 hours intravenously before neutron irradiation. Six patients received BNCT once and 3 twice. The estimated average gross tumor volume dose ranged from 22 to 38 Gy (W) (mean; 29 Gy [W]). Six of the 8 evaluable patients responded to BNCT; 2 achieved complete and 4 partial response. One patient died early and was not evaluable for response. Most common side effects were stomatitis, fatigue, and oral pain. No life-threa...Continue Reading

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Citations

Aug 18, 2020·Cancer Communications·Mayya Alexandrovna DymovaElena Vladimirovna Kuligina
Jun 20, 2018·Cancer Communications·Rolf F BarthTong Liu
Feb 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fayaz AliYinghuai Zhu
Mar 16, 2021·Critical Reviews in Oncology/hematology·Luca Giovanni LocatelloOreste Gallo
Mar 16, 2021·Frontiers in Oncology·Timothy D MalouffSunil Krishnan

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