Boron nitride nanotube-enhanced osteogenic differentiation of mesenchymal stem cells

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Xia LiDmitri Golberg

Abstract

The interaction between boron nitride nanotubes (BNNTs) layer and mesenchymal stem cells (MSCs) is evaluated for the first time in this study. BNNTs layer supports the attachment and growth of MSCs and exhibits good biocompatibility with MSCs. BNNTs show high protein adsorption ability, promote the proliferation of MSCs and increase the secretion of total protein by MSCs. Especially, BNNTs enhance the alkaline phosphatase (ALP) activity as an early marker of osteoblasts, ALP/total protein and osteocalcin (OCN) as a late marker of osteogenic differentiation, which shows that BNNTs can enhance osteogenesis of MSCs. The release of trace boron and the stress on cells exerted by BNNTs with a fiber structure may account for the enhanced differentiation of MSCs into osteoblasts. Therefore BNNTs are potentially useful for bone regeneration in orthopedic applications.

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Citations

Sep 25, 2016·Journal of Materials Science. Materials in Medicine·Xiang LuXuebin Zheng
Dec 30, 2017·Bone Research·Chengde GaoCijun Shuai
Jul 31, 2018·Biomaterials Science·A MerloI Mijakovic
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Feb 1, 2020·Science and Technology of Advanced Materials·Fu-Cheng KaoZong-Hong Lin
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Feb 2, 2021·Frontiers in Cell and Developmental Biology·Elia Bosch-RuéRoman A Perez
Jan 29, 2020·ACS Applied Materials & Interfaces·Anna M Brokesh, Akhilesh K Gaharwar
Mar 27, 2021·Biomedical Materials·Sathyan Vivekanand Anandhan, Uma Maheswari Krishnan
Sep 12, 2017·ACS Applied Materials & Interfaces·Sakthivel NagarajanMikhael Bechelany

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