Borrelia-associated crystalline keratopathy with intracorneal detection of Borrelia garinii by electron microscopy and polymerase chain reaction

Cornea
Tina DietrichBerthold Seitz

Abstract

First report of a patient with Borrelia-associated crystalline keratopathy with intracorneal evidence of Borrelia garinii by polymerase chain reaction (PCR) and electron microscopy (EM). Report of a 67-year-old patient with medical history of recurrent iridocyclitis and arthritis presented with a bilateral, progressive, asymmetric crystalline keratopathy, which was particularly pronounced in the peripheral temporal superior cornea. After penetrating keratoplasty, crystalline keratopathy with stromal haziness recurred. Corneal regrafting was performed. The corneal specimen from the penetrating keratoplasty was examined by light and EM as well as by PCR. In the explanted corneal graft, as well as retrospectively in the corneal specimen from the first keratoplasty, spirochetelike bodies and fragments were detected by light and EM. Borrelia burgdorferi sensu lato DNA was demonstrated by broad-range (16S rDNA) PCR. A more precise identification as Borrelia garinii serotype 5 was possible by analyses of the flaB and ospA gene sequences. Borrelia-specific serological tests showed borderline titers in immunofluorescence and weak reaction in immunoblot, respectively. This case illustrates that borreliae must be considered as a cause of ...Continue Reading

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Citations

Mar 27, 2012·Journal of Ophthalmic Inflammation and Infection·Timothy Y Chou, Rohit Adyanthaya
Apr 13, 2012·Cornea·Giovana MurilloMargarita Calonge
Nov 8, 2012·Cornea·Gregory W Oldham, Gerami D Seitzman
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul M LantosGary P Wormser
Oct 31, 2016·Survey of Ophthalmology·Harish RajaSophie J Bakri
Oct 18, 2016·Current Opinion in Ophthalmology·Saraniya Sathiamoorthi, Wendy M Smith
Dec 22, 2020·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Frederick M WangErin Kelleher
Jul 2, 2019·Médecine et maladies infectieuses·X GockoUNKNOWN endorsed by the following scientific societies
Jun 29, 2021·Survey of Ophthalmology·Arash MalekiC Stephen Foster
Jun 19, 2009·Current Opinion in Ophthalmology

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