Borrelia burgdorferi erp genes are expressed at different levels within tissues of chronically infected mammalian hosts

International Journal of Medical Microbiology : IJMM
Jennifer C Miller, Brian Stevenson

Abstract

The spirochete Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to humans and other vertebrate hosts through the bites of ixodid ticks. B. burgdorferi Erp (OspE-F related lipoprotein) family members are encoded on members of the 32 kb circular plasmid-like prophage family (cp32s). Many Erp proteins serve as receptors for the complement inhibitory factor H molecules of numerous vertebrate hosts, providing one mechanism by which the bacteria potentially evade the innate immune system. Indirect immunofluorescence analyses (IFA) have demonstrated that Erp expression is temporally regulated throughout the mammal-tick infectious cycle, indicating that Erp proteins perform an important role (or even roles) during mammalian infection. However, it was not previously known whether Erp proteins are continually produced by B. burgdorferi throughout the course of mammalian infection. To address this issue, quantitative RT-PCR (q-RT-PCR) was utilized to assess erp transcription levels by bacteria within numerous different tissues of both mice and non-human primates (NHPs) chronically infected with B. burgdorferi. Q-RT-PCR results obtained using both animal models indicated that while the majority of erp genes we...Continue Reading

References

Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·T G SchwanP A Rosa
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K SukE Fikrig
Mar 1, 1997·The Journal of Clinical Investigation·S DasE Fikrig
May 29, 1998·The Journal of Clinical Investigation·D R AkinsJ D Radolf
Feb 26, 2000·Infection and Immunity·J AnguitaE Fikrig
Apr 13, 2000·Journal of Bacteriology·J L BonoP Rosa
Feb 21, 2002·The Journal of Experimental Medicine·Fang Ting LiangMario T Philipp
Jun 18, 2002·Infection and Immunity·Emir HodzicStephen W Barthold
Jul 12, 2003·Microbiology·James A CarrollClaude F Garon
Apr 20, 2004·Journal of Bacteriology·Kelly BabbBrian Stevenson
May 19, 2004·International Journal of Medical Microbiology : IJMM·Peter KraiczyBrian Stevenson
Aug 28, 2004·The American Journal of Pathology·Fang Ting LiangErol Fikrig

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Citations

Nov 13, 2008·Infection and Immunity·Catherine A BrissetteBrian Stevenson
Dec 13, 2006·Wiener klinische Wochenschrift·Brian StevensonTomasz Bykowski
Feb 6, 2008·International Journal of Medical Microbiology : IJMM·Catherine A BrissetteBrian Stevenson
Jan 1, 2008·International Journal of Medical Microbiology : IJMM·Tomasz BykowskiBrian Stevenson
Mar 23, 2007·Molecular Microbiology·Qilong XuFang Ting Liang
Aug 1, 2006·Molecular Immunology·Suzan H M Rooijakkers, Jos A G van Strijp
Feb 28, 2009·Microbiology·Catherine A BrissetteBrian Stevenson
Nov 6, 2018·Ticks and Tick-borne Diseases·Simon BigelmayrPeter Kraiczy
Jul 3, 2021·Brain Sciences·Lenzie Ford, Danielle M Tufts

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