Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
R Sberro-SoussanChristophe Legendre

Abstract

Persistence of donor-specific anti-HLA antibodies (DSA) associated with antibody-mediated graft injuries following kidney transplantation predicts evolution toward chronic humoral rejection and reduced graft survival. Targeting plasma cells, the main antibody-producing cells, with the proteasome inhibitor bortezomib may be a promising desensitization strategy. We evaluated the in vivo efficacy of one cycle of bortezomib (1.3 mg/m(2)x 4 doses), used as the sole desensitization therapy, in four renal transplant recipients experiencing subacute antibody-mediated rejection with persisting DSA (>2000 [Mean Fluorescence Intensity] MFI). Bortezomib treatment did not significantly decrease DSA MFI within the 150-day posttreatment period in any patient. In addition, antivirus (HBV, VZV and HSV) antibody levels remained stable following treatment suggesting a lack of efficacy on long-lived plasma cells. In conclusion, one cycle of bortezomib alone does not decrease DSA levels in sensitized kidney transplant recipients in the time period studied. These results underscore the need to evaluate this new desensitization agent properly in prospective, randomized and well-controlled studies.

References

Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manisha H ShahMichael Grever
Oct 6, 2004·British Journal of Haematology·S JagannathK C Anderson
Dec 16, 2004·Pediatric Transplantation·Robert A Montgomery, Andrea A Zachary
Jun 17, 2005·The New England Journal of Medicine·Paul G RichardsonUNKNOWN Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigators
Jan 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasE S Kraus
Jan 24, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E J RamosJ P Grande
Feb 20, 2007·Cancer Research·Silke MeisterReinhard E Voll
Mar 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezJ J Weening
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D AnglicheauC Legendre
Jan 11, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D K PerryM D Stegall
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D K PerryM D Stegall
Dec 24, 2008·Transplantation·Matthew J EverlyE Steve Woodle
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guido BispingJoachim Kienast
May 23, 2009·Transplantation·Hargovind L TrivediShruti D Dave
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E S KrausR A Montgomery
Sep 25, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LoupyD Nochy

❮ Previous
Next ❯

Citations

Sep 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anne LemyDaniel Abramowicz
Dec 9, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas BarnettNizam Mamode
Aug 20, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johannes WaiserNils Lachmann
Feb 2, 2011·Transplantation·Tayyab S DiwanMark D Stegall
Mar 18, 2011·Transplantation·Allison WebberFlavio Vincenti
Apr 23, 2011·Transplantation·Silke V NiederhausArjang Djamali
Apr 30, 2013·Transplantation·Arend MulderFrans H J Claas
Oct 19, 2010·Journal of Transplantation·Rajeev RaghavanAbdul Abdellatif
May 12, 2012·Journal of Transplantation·Chethan PuttarajappaHenkie P Tan
Feb 27, 2013·Indian Journal of Nephrology·N S KrishnanR Higgins
Dec 12, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Janice G NigosKalathil K Sureshkumar
Feb 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rosanna Coppo
Jun 1, 2014·Current Transplantation Reports·Carrie Schinstock, Mark D Stegall
Mar 19, 2014·Antioxidants & Redox Signaling·Nicole S EjazE Steve Woodle
Feb 12, 2013·British Medical Bulletin·Junchao CaiPaul I Terasaki
May 1, 2012·Journal of Transplantation·Olivia R BlumeBruce Kaplan
Nov 25, 2011·Expert Opinion on Emerging Drugs·Lars P KihmChristian Morath
Sep 16, 2011·Expert Opinion on Investigational Drugs·Basma SadakaE Steve Woodle
Feb 3, 2011·Expert Opinion on Pharmacotherapy·Marcia KhoTeun van Gelder
Feb 8, 2011·Expert Opinion on Pharmacotherapy·Jessica G LucasKalathil K Sureshkumar
Feb 18, 2012·Kidney International·R Carlin WalshE Steve Woodle
Aug 21, 2012·Transplantation Reviews·Julio PascualMarta Crespo
Feb 3, 2012·Kidney International·Danielle CohenIngeborg M Bajema
Nov 29, 2011·Néphrologie & thérapeutique·Gwenaelle Roussey-Kesler, Stéphane Decramer
Dec 6, 2011·Transplantation Reviews·Daniel SerónAngel Alonso
Oct 5, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jignesh PatelJon Kobashigawa
Sep 24, 2011·Seminars in Immunology·Matthew H Levine, Peter L Abt
Feb 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
Aug 18, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Heiko BillingBurkhard Tönshoff
Dec 21, 2012·Annals of the New York Academy of Sciences·Alejandro M GomezMario Losen
Mar 8, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas Fehr, Ariana Gaspert
Jun 15, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R Clatworthy
Dec 16, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Undine A GerlachAndreas Pascher
Aug 13, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Gregor BartelGeorg A Böhmig
Jun 17, 2014·Pediatric Transplantation·Matthew D ZinnSanjeev Aggarwal
Nov 29, 2014·Clinical Transplantation·Stephanie A BurtonKaren L Hardinger
Apr 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D Kirk
Nov 28, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Undine A GerlachAndreas Pascher
Mar 24, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Vural Taner YilmazHuseyin Kocak
Dec 19, 2013·Clinical & Developmental Immunology·Sophia LionakiJohn N Boletis
May 28, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamad MohtyBeatrice Gaugler
Jul 15, 2015·Expert Opinion on Pharmacotherapy·Jamal BamoulidKlemens Budde

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved