PMID: 16614599Apr 15, 2006Paper

Bosentan for treatment of active digital ulcers in patients with systemic sclerosis

La Presse médicale
David LaunayEric Hachulla

Abstract

To describe the effect of bosentan and its dual inhibition of endothelin-1 ETA and ETB receptors on digital ulcers in patients with systemic sclerosis (SSc). Patients receiving bosentan for SSc-related digital ulcers were identified in eight centers, and their characteristics and follow-up were recorded. Nine (six with diffuse and three with limited cutaneous forms of SSc) patients (median age: 54 years) had received bosentan for digital ulcers. Complete healing occurred in seven (median time to improvement: 4 weeks). Another experienced a significant decrease in the number of ulcers (from 22 to 5) in 8 weeks, while one had no improvement. After a median follow-up of 24.3 months, only one recurrence was observed. Raynaud phenomenon improved in all but one patient. These data suggest that some patients may benefit from bosentan to treat digital ulcers. The short time to healing in these patients with rather chronic ulcers argues strongly in favor of its use. These results also strengthen the evidence that endothelin-1 plays an important role in the vascular manifestations of SSc. Bosentan can be effective in the treatment of digital ulcers in some SSc patients with SSc, probably especially those involving substantial ischemia. B...Continue Reading

Citations

Dec 8, 2007·Clinical Reviews in Allergy & Immunology·Norihito YazawaKunihiko Tamaki
Apr 5, 2007·The Annals of Pharmacotherapy·María Angeles González-Fernández, Julia García-Consuegra
Dec 21, 2016·Case Reports in Rheumatology·Emilio Giner Serret
May 5, 2020·The Cochrane Database of Systematic Reviews·Daniel G CacioneJose Cc Baptista-Silva
Apr 14, 2010·Nature Reviews. Rheumatology·Manuel Ramos-CasalsAntoni Sisó-Almirall
Mar 12, 2016·The Cochrane Database of Systematic Reviews·Daniel G CacioneJose C C Baptista-Silva
Nov 28, 2008·Rheumatology International·Masanori FunauchiK Kinoshita
Feb 16, 2012·BMC Cardiovascular Disorders·Joaquin De HaroLeticia Esparza
Sep 24, 2010·International Journal of Rheumatology·Elena SchiopuKristine Phillips
Nov 23, 2007·La Presse médicale·Camille FrancèsUNKNOWN Groupe français de recherche sur la sclérodermie

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