Abstract
Bosentan, an oral, dual endothelin receptor antagonist, significantly improves functional status, haemodynamic measures and survival in patients with pulmonary arterial hypertension (PAH). However, there are limited data on the effect of bosentan on quality of life (QOL) and its relationship to changes in functional status, as measured by the 6 minute walk distance (6MWD). A retrospective analysis was performed of a large, open-label, multicentre trial (VITAL) of bosentan in patients with PAH. Data for 6MWD were collected at baseline, 3 or 6 months and these results were correlated with QOL measurements collected as part of the assessment of patients enrolled in the trial. Sixty-nine patients with PAH (mean age 52 years) who were enrolled in the trial had valid QOL (SF-36) measurements and 6MWD data that could be retrieved from clinical notes. At 3 and 6 months, bosentan therapy improved 6MWD compared with baseline (49.5 m and 47.2 m, respectively, P < 0.001) as well as QOL domains, with a significant correlation between these two markers on cross-sectional analysis. However, there was a poor relationship when comparing changes in 6MWD with changes in QOL, in response to therapy. Bosentan therapy was associated with improvement...Continue Reading
References
Oct 1, 1992·American Heart Journal·T S Rector, J N Cohn
Jun 11, 1992·Medical Care·J E Ware, C D Sherbourne
Sep 1, 1991·Annals of Internal Medicine·G E D'AlonzoJ T Kernis
May 1, 1981·Social Science & Medicine. Part A, Medical Sociology·S M HuntE Papp
Jan 4, 1995·JAMA : the Journal of the American Medical Association·I B Wilson, P D Cleary
Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
Mar 28, 1996·The New England Journal of Medicine·M A Testa, D C Simonson
Jan 6, 1999·Heart·S T O'KeeffeD N Carmichael
Nov 5, 1990·Health Policy·UNKNOWN EuroQol Group
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·C J ArchibaldK M Moser
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·S MiyamotoK Miyatake
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R ChannickL J. Rubin
Oct 13, 2001·Lancet·R N ChannickL J Rubin
Feb 16, 2002·Heart·J JuengerM Haass
Mar 19, 2002·American Journal of Respiratory and Critical Care Medicine·Gerald SimonneauUNKNOWN Treprostinil Study Group
Mar 22, 2002·The New England Journal of Medicine·Lewis J RubinGerald Simonneau
Aug 2, 2002·The New England Journal of Medicine·Horst OlschewskiUNKNOWN Aerosolized Iloprost Randomized Study Group
Apr 23, 2003·Journal of the American College of Cardiology·Nazzareno GalièLewis Rubin
Jul 11, 2003·Chest·Olivier SitbonLewis J Rubin
Mar 23, 2004·European Heart Journal·Ghada W MikhailMichael A Gatzoulis
Apr 6, 2004·Journal of the American College of Cardiology·B K S SastryB Soma Raju
Jun 15, 2004·Journal of the American College of Cardiology·Marius M HoeperAdam Torbicki
Nov 13, 2004·Chest·Shirin ShafazandMichael K Gould
Feb 3, 2005·The European Respiratory Journal·V V McLaughlinL J Rubin
Jun 23, 2005·Current Medical Research and Opinion·Rogerio SouzaHumberto Bogossian
Aug 12, 2005·Respiratory Research·Darren B TaichmanHarold Palevsky
Jan 30, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Anne M KeoghTrevor J Williams
Citations
Dec 22, 2010·Lung·Omar BatalOmar A Minai
May 18, 2013·Lung·Michael HalankVolker Köllner
Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Mar 13, 2010·Journal of Transplantation·Babak DaftariGregory Perens
Jul 13, 2013·BMC Pulmonary Medicine·James TwissEli Gabbay
Jan 1, 2009·Journal of Multidisciplinary Healthcare·Geoff StrangeEli Gabbay
Jun 16, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Geoff StrangeEli Gabbay
Nov 23, 2013·Expert Opinion on Drug Safety·Jasper DingemanseHani Mickail
Mar 5, 2013·Archivos de bronconeumología·Antonio RomanPilar Escribano
Nov 26, 2010·Drug Discovery Today·Harald E HeemstraM Miles Braun
Jun 24, 2006·Critical Care : the Official Journal of the Critical Care Forum·Doug ElliottMadeleine T King
Oct 11, 2017·Lung·Elena PfeufferMatthias Held
Nov 16, 2013·Journal of Biomechanical Engineering·Flavio Firmani, Edward J Park
Dec 17, 2009·Current Opinion in Rheumatology