Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Neural Plasticity
Enrico SangiovanniFrancesca Calabrese

Abstract

The involvement of brain-derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored. The present review considers the literature on the effects of botanicals on BDNF. Botanicals considered were Bacopa monnieri (L.) Pennell, Coffea arabica L., Crocus sativus L., Eleutherococcus senticosus Maxim., Camellia sinensis (L.) Kuntze (green tea), Ginkgo biloba L., Hypericum perforatum L., Olea europaea L. (olive oil), Panax ginseng C.A. Meyer, Rhodiola rosea L., Salvia miltiorrhiza Bunge, Vitis vinifera L., Withania somnifera (L.) Dunal, and Perilla frutescens (L.) Britton. The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well. The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators. The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side ...Continue Reading

References

Nov 1, 1991·Academic Medicine : Journal of the Association of American Medical Colleges·J S Samkoff, C H Jacques
Jul 1, 1997·Brain Research. Molecular Brain Research·K N SalimH M Chao
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Mar 29, 2003·Learning & Memory·Bai Lu
May 24, 2005·The Korean Journal of Internal Medicine·Ka Yeoung YiHeung Bum Lee
Aug 3, 2005·Nature Reviews. Neuroscience·Bai LuNewton H Woo
Dec 7, 2006·Journal of Neuroscience Research·Tamara AidTõnis Timmusk
Aug 30, 2007·Nature Neuroscience·Keri MartinowichBai Lu
May 24, 2008·Novartis Foundation Symposium·Bai Lu, Keri Martinowich
Jun 23, 2009·Psychoneuroendocrinology·Francesca CalabreseMarco A Riva
Jul 28, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Haixia DangYuqing Wang
Jan 13, 2010·Free Radical Biology & Medicine·Marco AssunçãoJosé P Andrade
Apr 10, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A PanossianJ Sarris
Apr 14, 2010·The European Journal of Neuroscience·Ibrahim A AlhaiderKarim A Alkadhi
Apr 27, 2010·Journal of Asian Natural Products Research·Zheng-Feng LuQi-Rong Dong
May 22, 2010·The Journal of Pharmacy and Pharmacology·Bombi LeeDae-Hyun Hahm
May 25, 2010·Biochemical and Biophysical Research Communications·Sean Connolly, Tami J Kingsbury
Feb 23, 2011·Molecular and Cellular Neurosciences·Ibrahim A AlhaiderKarim A Alkadhi
Mar 2, 2011·Nature Reviews. Drug Discovery·Alan H Nagahara, Mark H Tuszynski
Aug 24, 2011·Psychopharmacology·Chisato WakabayashiHiroshi Kunugi
Sep 29, 2011·Journal of Psychopharmacology·Jihong CuiHui Xiang

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Citations

Nov 28, 2019·International Journal of Molecular Sciences·Elisa LanducciMaria Camilla Bergonzi
May 8, 2019·Human & Experimental Toxicology·E J CalabreseW J Kozumbo
Nov 22, 2019·Frontiers in Neuroscience·Susan Westfall, Giulio Maria Pasinetti
Dec 24, 2020·International Journal of Molecular Sciences·Donald David Haines, Arpad Tosaki
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beatriz G MuratoriSuzete M Cerutti
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jin-Seok LeeChang-Gue Son
Nov 12, 2021·Frontiers in Cellular and Infection Microbiology·Ruihua DongNa He

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