PMID: 8952964Jan 1, 1996Paper

Both alpha and beta chain polymorphisms determine the specificity of the disease-associated HLA-DQ2 molecules, with beta chain residues being most influential

Immunogenetics
B H JohansenL M Sollid

Abstract

We compared the peptide binding specificity of three HLA-DQ molecules; HLA-DQ(alpha1(*)0501, beta1(*)0201), HLA-DQ(alpha1(*)0201, beta1(*)0202), and HLA-DQ(alpha1(*)0501, beta1(*)0301). The first of these molecules confers susceptibility to celiac disease and insulin-dependent diabetes mellitus, while the two latter molecules, which share either the alpha chain or the nearly identical beta chain with HLA-DQ(alpha1(*)0501, beta1(*)0201), do not predispose to these disorders. The binding of peptides was detected in biochemical binding assays as inhibition of binding of radiolabeled indicator peptides to affinity-purified HLA-DQ molecules. Binding experiments with several peptides demonstrated a clear difference in peptide binding specificity between the three HLA-DQ molecules. Further, single amino acid substitution analyses indicated that the HLA-DQ molecules have different peptide binding motifs. The experimental data were corroborated by computer modelling analysis. Our data suggest that the three HLA-DQ molecules prefer large hydrophobic residues in P1 of peptides with subtle differences in side-chain preferences. HLA-DQ(alpha1(*)0501, beta1(*)0201) and HLA-DQ(alpha1(*)0201, beta1(*)0202) both prefer large hydrophobic residue...Continue Reading

Citations

Aug 24, 1999·European Journal of Immunology·H QuarstenL M Sollid
Apr 27, 2012·Seminars in Immunopathology·Shuo-Wang QiaoLudvig M Sollid
Mar 1, 1997·Human Immunology·E Thorsby
Mar 6, 2002·The Journal of Experimental Medicine·L Willemijn VaderFrits Koning
Jan 4, 2007·The Journal of Clinical Investigation·Martin F Kagnoff
Nov 26, 2015·Seminars in Immunology·J Stamnaes, L M Sollid
Oct 24, 2003·Protein Science : a Publication of the Protein Society·Maria Fiorella MazzeoRosa Anna Siciliano
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Yuping WuAnlong Xu
Dec 9, 2014·The Journal of Clinical Investigation·Hiroko MiyaderaKatsushi Tokunaga
Jun 22, 2018·Nature Immunology·Elena F Verdu, Jayne S Danska
Jan 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yi Tian TingJamie Rossjohn
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florence A CastelliBernard Maillère
Apr 13, 2005·Gastroenterology·Martin F Kagnoff

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