PMID: 8975843Dec 1, 1996Paper

Both blood and crystalloid-based extracellular solutions are superior to intracellular solutions for lung preservation

The Journal of Thoracic and Cardiovascular Surgery
O A BinnsI L Kron

Abstract

Lung transplantation remains limited by donor organ ischemic time, inadequate graft preservation, and reperfusion injury. We evaluated lung preservation with use of an extracellular solution, with or without the addition of blood, as compared with preservation with the intracellular Euro-Collins solution. With use of an isolated, whole blood perfused/ventilated rabbit lung model, we studied three groups of animals. Lungs were flushed with Euro-Collins, low-potassium dextran, or 20% blood-low-potassium dextran solution. Lungs were harvested en bloc, stored inflated at 4 degrees C for 18 hours, and then reperfused at 60 ml/min with whole blood. Continuous measurements of pulmonary artery pressure, pulmonary vascular resistance, and dynamic airway compliance were obtained. Fresh, nonrecirculated venous blood was used to determine the single-pass pulmonary venous-arterial oxygen gradient. Lungs preserved with Euro-Collins solution demonstrated elevated pulmonary artery pressure and pulmonary vascular resistance when compared with those preserved with low-potassium dextran and 20% blood-low-potassium dextran solutions (pulmonary artery pressure: 40.8 +/- 2.2 mm Hg vs 28.9 +/- 2.4 mm Hg and 28.3 +/- 1.5 mm Hg, respectively, p < 0.001...Continue Reading

References

Sep 1, 1991·The Annals of Thoracic Surgery·P O KimbladS Steen
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Mar 1, 1996·The Annals of Thoracic Surgery·N F DeLimaI L Kron
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Jul 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·N F DeLimaI L Kron
Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·O A BinnsI L Kron

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Citations

Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Matthias PeltzDan M Meyer
Sep 7, 2005·Respiratory Physiology & Neurobiology·Matthias PeltzDan M Meyer
Sep 2, 1998·The Annals of Thoracic Surgery·K TakigamiK Yasuda
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·L XiongP Menasché
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·O D SchneuwlyD R Morel
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·A FehrenbachH Fehrenbach
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·G ThabutH Mal
Nov 28, 2000·The Annals of Thoracic Surgery·M A MathiasI L Kron
Mar 26, 1999·The Journal of Surgical Research·A FehrenbachJ Richter
Dec 29, 2000·The Journal of Laboratory and Clinical Medicine·R F Kelly

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