Both caspase-dependent and caspase-independent pathways may be involved in hippocampal CA1 neuronal death because of loss of cytochrome c From mitochondria in a rat forebrain ischemia model

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R Z ZhanK Shimoji

Abstract

In a rat forebrain ischemia model, the authors examined whether loss of cytochrome c from mitochondria correlates with ischemic hippocampal CA1 neuronal death and how cytochrome c release may shape neuronal death. Forebrain ischemia was induced by bilateral common carotid artery occlusion with simultaneous hypotension for 10 minutes. After reperfusion, an early rapid depletion of mitochondrial cytochrome c and a late phase of diffuse redistribution of cytochrome c occurred in the hippocampal CA1 region, but not in the dentate gyrus and CA3 regions. Intracerebroventricular administration of Z-DEVD-FMK, a relatively selective caspase-3 inhibitor, provided limited but significant protection against ischemic neuronal damage on day 7 after reperfusion. Treatment with 3 minutes of ischemia (ischemic preconditioning) 48 hours before the 10-minute ischemia attenuated both the early and late phases of cytochrome c redistribution. In another subset of animals treated with cycloheximide, a general protein synthesis inhibitor, the late phase of cytochrome c redistribution was inhibited, whereas most hippocampal CA1 neurons never regained mitochondrial cytochrome c. Examination of neuronal survival revealed that ischemic preconditioning pre...Continue Reading

References

May 15, 1976·The Biochemical Journal·A BoverisA O Stoppani
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KirinoA Tamura
Sep 24, 1990·Brain Research·K KitagawaK Mikoshiba
Sep 3, 1986·Brain Research·Y Takahata, K Shimoji
Jan 1, 1985·Progress in Biophysics and Molecular Biology·F S Mathews
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Jan 8, 1996·FEBS Letters·C RichterC Franceschi
Sep 15, 1996·The Biochemical Journal·G E KassS C Chow
Nov 1, 1996·Brain Research. Molecular Brain Research·J HonkaniemiF R Sharp
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J ChenR P Simon
Mar 10, 1997·The Journal of Cell Biology·K FurukawaM P Mattson
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M EndresM A Moskowitz
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M JürgensmeierJ C Reed
Jun 13, 1998·The Journal of Biological Chemistry·J Cai, D P Jones
Sep 23, 1998·The Journal of Cell Biology·S J NeameK L Philpott
Apr 10, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G FiskumM F Beal
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·S KrajewskiJ C Reed
Oct 3, 1999·Physiological Reviews·P Lipton

❮ Previous
Next ❯

Citations

Mar 5, 2009·Cellular and Molecular Neurobiology·Viera DanielisováJozef Burda
Apr 20, 2005·Brain Research. Molecular Brain Research·Zhaohui DongCarol A Miller
Jun 8, 2001·Journal of Neuroscience Methods·C WuK Shimoji
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
Sep 5, 2002·Free Radical Biology & Medicine·Bin WuKazuma Fujimoto
Mar 24, 2005·Journal of Cellular and Molecular Medicine·M SlevinS Kumar
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kunjan R DaveMiguel A Perez-Pinzon
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Alexander G Yakovlev, Alan I Faden
May 26, 2007·Neurochemistry International·Małgorzata Ziemka-Nałecz, Teresa Zalewska
Feb 18, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Sven NaetzkerGerhild Echten-Deckert
Jan 9, 2013·The Journal of Comparative Neurology·Todd H AhernNancy G Forger
Nov 22, 2011·The European Journal of Neuroscience·Sara BarberanBrian J Morris
Feb 6, 2010·The American Journal of Pathology·Jiqiu ChenSima T Tarzami
May 26, 2004·Brain Research. Developmental Brain Research·Genell D HiltonMargaret M McCarthy
Dec 5, 2014·Expert Opinion on Therapeutic Targets·Christos BikisStamatios Theocharis
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Kevin Pong
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·S Thomas Carmichael
May 21, 2016·The Journal of Comparative Neurology·Morgan MosleyNancy G Forger
Mar 3, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Makiko NiimuraSatoshi Takeo
Feb 17, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julian CahillJohn H Zhang
Jun 8, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Heng ZhaoGary K Steinberg
Jan 18, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ren-Zhi ZhanRochelle D Schwartz-Bloom
Jun 17, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ren-Zhi ZhanRochelle D Schwartz-Bloom
Dec 17, 2003·Journal of Neurosurgical Anesthesiology·Rona G Giffard, Midori A Yenari
Jul 11, 2003·Annals of the New York Academy of Sciences·Anya M Y LinLow-Tone Ho
May 23, 2006·Nature Reviews. Neuroscience·Jeffrey M Gidday
May 3, 2006·Cerebrovascular Diseases·Isidro Ferrer
Jul 31, 2002·The Journal of Cell Biology·Sean P CreganRuth S Slack
Aug 3, 2004·Critical Care Medicine·Evangelos MessarisGeorge Androulakis
Apr 30, 2003·Anesthesiology·Rona G Giffard, Gary Fiskum
Dec 21, 2004·Brain Pathology·Georg Johannes MüllerFlemming Fryd Johansen

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
electrophoresis

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.