Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment.

Nutrition Journal
Keith R Martin

Abstract

Cardiovascular disease (CVD) is a leading cause of mortality in the United States as well as globally. Epidemiological studies show that regular fruit and vegetable consumption reduces CVD risk, in part, due to antioxidant activity and immunomodulation since oxidative stress and inflammation are features of atherogenesis. Accumulating evidence also shows that dietary fungi, viz., mushrooms, can protect against chronic disease by altering inflammatory environments such as those associated with CVD although most research has focused on specialty mushrooms. In this study, we tested the ability of both common and specialty mushrooms to inhibit cellular processes associated with CVD. Human aortic endothelial cells (HAEC) were incubated overnight with control media with dimethylsulfoxide (DMSO) vehicle (1% v/v) or containing DMSO extracts of whole dehydrated mushrooms (0.1 mg/mL), which included Agaricus bisporus (white button and crimini), Lentinula edodes (shiitake), Pleurotus ostreatus (oyster), and Grifola frondosa (maitake). Monolayers were subsequently washed and incubated with medium alone or containing the pro-inflammatory cytokine IL-1beta (5 ng/mL) for 6 h to upregulate pro-atherosclerotic adhesion molecules (AM). AM expres...Continue Reading

References

Jul 1, 1991·Archives of Biochemistry and Biophysics·D AkanmuB Halliwell
Apr 1, 1985·The Journal of Clinical Investigation·P E DiCorleto, C A de la Motte
Apr 22, 1994·Science·W C Willett
Nov 1, 1996·Nutrition Reviews·R Chang
Aug 26, 1998·Journal of the American College of Nutrition·L M Klevay
Nov 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O I AruomaN Mahmood
Jul 25, 2000·Nutrition·P MattilaV Piironen
Jun 20, 2001·Annals of Internal Medicine·K J JoshipuraW C Willett
Sep 27, 2002·European Heart Journal·N T MulvihillM Walsh
Oct 3, 2002·Journal of Agricultural and Food Chemistry·Jeng-Leun MauChin-Chu Chen
Dec 12, 2002·Journal of Agricultural and Food Chemistry·Yanjun ZhangMuraleedharan G Nair
Dec 5, 2003·Archives of Biochemistry and Biophysics·Marco ValgimigliRoberto Ferrari
Apr 21, 2004·Experimental Biology and Medicine·Andrea T BorchersM Eric Gershwin
Jun 10, 2004·Atherosclerosis·Liping LiuMohsen Meydani
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jul 28, 2005·FEMS Microbiology Letters·Shih Chung ChenDanny Ling Wang
Jan 31, 2006·The American Journal of Cardiology·Steven M Haffner
Feb 14, 2006·The American Journal of Clinical Nutrition·Raffaele De CaterinaMarika Massaro
Feb 26, 2008·Experimental Biology and Medicine·Andrea T BorchersM Eric Gershwin
Jun 17, 2008·European Journal of Nutrition·Theo M de KokMargaret M Manson
Jan 30, 2010·Current Problems in Cardiology·Thomas A GazianoAdrianna Murphy

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Citations

Oct 31, 2015·Critical Reviews in Biotechnology·Mohammad Azizur RahmanNorhaniza Aminudin
Sep 25, 2014·Bioscience, Biotechnology, and Biochemistry·Hyeon Soo ParkGon Sup Kim
Sep 7, 2016·Journal of Immunology Research·Gianandrea GuidettiGiuseppe Terrazzano
Aug 21, 2021·Critical Reviews in Biotechnology·Mohan Prasad SinghNarsingh Bahadur Singh

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Methods Mentioned

BETA
light microscopy
ELISA

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