Both d- and l-glutamate induce transporter-mediated presynaptic autoinhibition of transmitter release

The European Journal of Neuroscience
J Dudel

Abstract

In crayfish motor nerve terminals l-glutamate (Glu) is the excitatory transmitter and low l-Glu concentrations exert autoinhibition by inhibiting release of Glu quanta from the terminals. This autoinhibition has been shown to be mediated by binding and transport of l-Glu by Glu transporters in the presynaptic membrane. Activated transporters open an associated Cl(-) channel and inhibit release [J. Dudel & M. Schramm (2003) Eur. J. Neurosci., 18, 902-910]. The excitatory, glutamatergic synaptic transmission is specific for the l-Glu isomer. However, transporters are non-selective for the stereoisomers. It is shown here that low concentrations (5 micro m) of d- as well as l-Glu inhibit quantal release on average to 55 and 68%, respectively. The power of inhibition varies widely at different terminals but the local sensitivity to d-Glu is seen to be the same as that for l-Glu. l-Glutamate has been reported to reduce the mean amplitude of nerve terminal action currents (excitatory nerve terminal currents) by about 10%, presumably due to the opening of Cl(-) channels. Evidence is given that d-Glu also inhibits this by an average of 10% (P < 0.001), as expected if both l- and d-Glu activate a transporter-associated Cl(-) conductance....Continue Reading

References

May 6, 1977·Pflügers Archiv : European journal of physiology·J Dudel
Jul 1, 1989·Physiological Reviews·K StarkeH Kilbinger
Jan 31, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
Aug 1, 1966·Comparative Biochemistry and Physiology·I Parnas, H L Atwood
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·H ParnasB Yudelevitch
Aug 20, 2003·The European Journal of Neuroscience·Josef Dudel, Marion Schramm
May 10, 1965·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J DUDEL
Nov 12, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Anne-Ulrike TrendelenburgKlaus Starke

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Citations

May 28, 2005·Current Opinion in Neurobiology·Mark S SondersJonathan A Javitch
Jun 12, 2016·Journal of the Neurological Sciences·Toshio Obata, Michiko Nakashima
Mar 5, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hai HanKenji Hamase

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