PMID: 9442401Jan 27, 1998Paper

Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa

Immunobiology
L J StroblU Zimber-Strobl

Abstract

The Epstein-Barr viral nuclear antigen 2 (EBNA2) plays a key role during establishment and maintenance of B cell immortalization after Epstein-Barr virus (EBV) infection. EBNA2 acts as a transactivator of cellular and viral genes. We studied two EBNA2 regulated viral promoters (TP1 promoter and LMP/TP2 promoter) in detail to learn more about the molecular mechanisms of EBNA2-mediated transactivation. In both promoters we could identify at least one binding site for the cellular repressor protein RBP-J kappa. EBNA2 is tethered to the EBNA2 responsive promoter elements by interaction with this cellular protein. Although necessary, the binding of RBP-J kappa is not sufficient for EBNA2-mediated transactivation. At least two further cellular proteins, which are different in the studied promoters are important for efficient transactivation. The identification of RBP-J kappa as central mediator of EBNA2 transactivation suggested an interference of EBNA2 with the highly conserved Notch receptor signal transduction pathway. We could show that an activated form of the Notch receptor can transactivate a reporter construct containing a hexamer of the two RBP-J kappa binding sites of the TP1 promoter supporting the idea that EBNA2 acts as ...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R FåhraeusL Rymo
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J I CohenE Kieff
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F WangE Kieff
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·G MillerM Lipman
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S R GrossmanE Kieff
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KayeE Kieff
Oct 1, 1996·Histopathology·I Anagnostopoulos, M Hummel
Nov 1, 1996·The Journal of General Virology·M BrielmeierW Hammerschmidt

❮ Previous
Next ❯

Citations

Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H zur Hausen
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H zur Hausen
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·E D Cahir-McFarlandE Kieff
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lucio Miele
Sep 15, 2010·The Journal of Biological Chemistry·Linchao LuPamela Stanley
Dec 7, 2010·The Journal of Biological Chemistry·Stefano ZanottiErnesto Canalis
Nov 15, 2011·The Journal of Biological Chemistry·Xinghua HouPamela Stanley
Nov 21, 2012·The Journal of Biological Chemistry·Stefano ZanottiErnesto Canalis
Jun 28, 2008·The Journal of Biological Chemistry·Anna Smerdel-RamoyaErnesto Canalis
Mar 19, 2008·The Journal of Biological Chemistry·Mark StahlPamela Stanley
Jun 3, 2000·The EMBO Journal·T Schroeder, U Just
Jul 14, 2000·AIDS·D J BlackbournJ A Levy
Jul 19, 2005·Genes & Development·Vincent ZecchiniPhil Jones
Feb 13, 2001·Journal of Virology·I HanE Kieff
Apr 30, 2003·Journal of Virology·Lisa M JohansenElizabeth J Taparowsky
Oct 18, 2005·Molecular and Cellular Biology·Shaolin ShiPamela Stanley
Apr 19, 2008·Endocrinology·Stefano ZanottiErnesto Canalis
Mar 16, 2011·Journal of Cell Science·Youping SunSpyros Artavanis-Tsakonas
Jul 14, 2012·PloS One·Hiroko NagaoSetsuro Komiya
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Timm SchroederUrsula Just
Nov 15, 2008·Leukemia Research·Leonardo MirandolaRaffaella Chiaramonte
Aug 26, 2009·Scandinavian Journal of Immunology·C HoennscheidtM S Staege
Jun 29, 2011·International Journal of Cancer. Journal International Du Cancer·Henrik GrossFriedrich A Grässer
Jul 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Valerie DeregowskiErnesto Canalis
Aug 21, 2013·Osteoarthritis and Cartilage·S Zanotti, E Canalis
Jul 28, 2004·The American Journal of Pathology·Hippokratis KiarisSpyros Artavanis-Tsakonas
Apr 24, 2008·Molecular Immunology·Dörte SiemerRalf Küppers
Feb 3, 2005·Oncogene·Lindsay C SpenderPaul J Farrell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.