PMID: 6976958Dec 1, 1981Paper

Both HLA-DR restricted and nonrestricted functions of adherent cells are required for induction of T lymphocyte proliferative responses

Human Immunology
Y KoideT O Yoshida

Abstract

There appeared to be two distinct functions of adherent cells in human T lymphocyte proliferative responses to purified protein derivative (PPD). The first is antigen-presenting ability which is mediated by antigen-presenting cells (APC) among adherent cells. By employing antiserum blocking pretreatment of APC, it was revealed that HLA-DR antigens are involved in this function and that identity or partial identity of HLA-DR antigens between APC and T lymphocytes is required for T lymphocyte antigen recognition. The second function is mediated by the soluble factor produced by adherent cells and is HLA-DR nonrestricted. Although it remains unclear whether APC and adherent cells producing the soluble factor belong to the same cell population, this second function might lead T lymphocytes to proliferative as long as T lymphocytes recognize antigen (PPD) via APC.

References

Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R S GehaE J Yunis
Nov 1, 1977·The Journal of Experimental Medicine·M Taniguchi, J F Miller

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.