Both ipsilateral and contralateral localized vibratory stimulations modulated pain-related sensory thresholds on the foot in mice and humans

Journal of Pain Research
Atsushi DoiMegumu Yoshimura

Abstract

This study was aimed to investigate the effect of localized vibration on sensory thresholds in mice and humans using a novel quantitative method. The sensory thresholds of 7-week-old male C57BL/6J mice were measured with four sine-wave electrostimulation frequencies (5, 50, 250, and 2,000 Hz) before and after applying 2-minute vibration to the plantar side of the foot in mice. In human participants (16 males and 16 females; mean age, 21.0±0.8 years), the sensory threshold was measured at 50 Hz before and after applying 2-minute and 5-minute vibrations to the dorsal side of the foot. Application of a 2-minute vibration at either the ipsilateral or contralateral side modulated the sensory thresholds elicited by a 5- or 50-Hz right electrostimulation in mice. In human participants, application of a 5-minute vibration at either the ipsilateral or contralateral side modulated the sensory threshold elicited by 50-Hz right electrostimulation, but had no effect on local skin temperature. These results suggest that the right side of pain-related Aδ fibers (50 Hz) or C fibers (5 Hz) was modulated by the localized ipsilateral or contralateral side of vibratory stimuli, respectively, in mice and humans. The ability of contralateral vibrati...Continue Reading

Citations

Dec 9, 2020·International Journal of Environmental Research and Public Health·Elisa Benito-MartínezBeatriz Alonso-Cortés
Nov 13, 2020·Journal of Exercise Rehabilitation·Taiki NakataMegumu Yoshimura

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