PMID: 11916766Mar 28, 2002Paper

Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells

The American Journal of Clinical Nutrition
Priya MohantyParesh Dandona

Abstract

It was recently shown that glucose challenge leads to increased generation of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMNs) and mononuclear cells (MNCs). To further elucidate the relation between nutrition and ROS generation, we investigated the effect of lipid and protein challenges on ROS generation by leukocytes. After having fasted overnight, one group of healthy subjects consumed a carbohydrate- and protein-free cream preparation (1257 kJ) and another group of healthy subjects consumed an equienergetic pure preparation of casein. Sequential blood samples were obtained after the intake of cream and casein. ROS were measured by chemiluminescence after stimulation by N-formyl-methionyl-leucinyl-phenylalanine. Lipid peroxidation was measured as thiobarbituric acid-reactive substances (TBARS) and alpha-tocopherol was measured by HPLC. ROS generation by MNCs and PMNs increased significantly 1, 2, and 3 h after cream intake and 1 h after protein intake. Cholesterol concentrations did not change significantly, whereas triacylglycerol concentrations increased significantly 2 h after cream intake. Total TBARS concentrations increased 1 h after cream intake and remained elevated 3 h after intake, but the increa...Continue Reading

References

Apr 1, 1992·American Journal of Clinical Pathology·M F Tosi, A Hamedani
Aug 28, 1992·Science·E R Stadtman
Feb 20, 1986·The New England Journal of Medicine·R Ross
Mar 1, 1995·Drugs·S R Maxwell
Feb 17, 1996·Lancet·P DandonaT Nicotera
Jul 17, 1998·Metabolism: Clinical and Experimental·P DandonaA Chaudhuri
Sep 4, 1998·Diabetes Care·A CerielloC Taboga
Dec 24, 1998·JAMA : the Journal of the American Medical Association·D OrnishR J Brand
Jan 14, 1999·The New England Journal of Medicine·R Ross
Aug 18, 2000·The Journal of Clinical Endocrinology and Metabolism·P MohantyP Dandona

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Citations

Jul 29, 2003·Diabetes·Gunnar EngströmFolke Lindgärde
Feb 20, 2004·Current Hypertension Reports·Undurti N Das
Nov 25, 2004·Diabetes Care·Zachary T Bloomgarden
Oct 27, 2005·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezJohn P Kirwan
Nov 1, 2005·Current Atherosclerosis Reports·Helen K Delichatsios, Francine K Welty
Feb 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezJohn P Kirwan
Apr 8, 2006·The American Journal of Clinical Nutrition·Sidika E Kasim-KarakasIshwaral Jialal
Nov 10, 2006·The American Journal of Clinical Nutrition·Marjan J van ErkHenk F J Hendriks
May 17, 2007·Arquivos brasileiros de endocrinologia e metabologia·Luiz Guilherme K de AguiarEliete Bouskela
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Ahmad Aljada
Jan 22, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Nov 13, 2009·Diabetes Care·Daniele VersariStefano Taddei
Dec 14, 2011·Molecular Carcinogenesis·Donghui Li
Jan 26, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stephanie P KurtiCraig A Harms
May 23, 2017·Frontiers in Endocrinology·Lewan ParkerItamar Levinger
Aug 5, 2017·Diabetes Technology & Therapeutics·Paresh Dandona
Jul 1, 2010·Expert Review of Endocrinology & Metabolism·Undurti N Das
Dec 11, 2019·Nutrients·Emma C E MeessenMaarten R Soeters
May 13, 2020·Archives of Physiology and Biochemistry·Shambhoo Sharan TripathiSyed Ibrahim Rizvi
Sep 15, 2004·Circulation·Husam GhanimParesh Dandona
Dec 23, 2006·Clinical and Experimental Pharmacology & Physiology·Jeroen van WijkJorge Joven
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Ahmad AljadaParesh Dandona
Dec 2, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Moreno-NavarreteJ M Fernández-Real
Jul 28, 2013·Journal of the American College of Nutrition·Rogelio U Almario, Sidika E Karakas
Feb 6, 2017·BoneKEy Reports·Robert MacDonellCarlos M Isales
Jun 29, 2017·Immunological Reviews·Philip M HansbroJay C Horvat
Aug 3, 2016·Menopause : the Journal of the North American Menopause Society·Zhao-Min LiuJean Woo
May 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ariana PicuMariana Carmen Chifiriuc
Nov 8, 2017·Frontiers in Immunology·Awad AlshahraniAhmad Aljada
Nov 22, 2017·Annals of the American Thoracic Society·Lisa G Wood
Jul 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezAnthony J Acton
Mar 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezAnthony J Acton
Aug 12, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mahdieh Abbasalizad FarhangiPourya Fathollahi

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