Both localized and systemic bacterial infections are predicted by injection drug use: A prospective follow-up study in Swedish criminal justice clients

PloS One
Disa DahlmanAnders Håkansson

Abstract

Both skin and soft tissue infections (SSTI) and systemic bacterial infections are common in people who inject drugs (PWID), but data on incidence and risk factors are lacking. We compared registered diagnoses for such infections in Swedish criminal justice clients with regard to injecting drug use. Baseline interview data from the Swedish Prison and Probation Service on drug use in PWID and non-PWID with problematic alcohol use were linked to follow-up data from national Swedish registers on hospital diagnoses and/or death. Associations between drug use and later diagnosis of SSTI and systemic bacterial infection (septicemia or bacterial infection of the heart, bone/joints or central nervous system) were analyzed by Cox regression. Incidence rates of SSTI was 28.3 per 1,000 person-years for PWID (n = 2,444) and 10.0 for non-PWID with problematic alcohol use (n = 735). Incidence rates of systemic bacterial infection was 9.1 per 1,000 person-years for PWID and 2.7 per 1,000 person-years for non-PWID. Injection drug use was associated with a significantly increased risk of bacterial infections, for main drugs heroin (SSTI: Hazard ratio [HR] 2.45; systemic infection: HR 2.75), amphetamine (SSTI: HR 1.60; systemic infection: HR 2.19...Continue Reading

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Citations

Dec 12, 2020·Infectious Disease Clinics of North America·Henry F Chambers
Dec 15, 2020·The Journal of Applied Laboratory Medicine·Matthew LloydChristopher W Farnsworth
Mar 19, 2021·ACS Infectious Diseases·Carly DeusenberyAnita Shukla
Aug 13, 2020·Infectious Disease Clinics of North America·Carlos S SaldanaAlysse G Wurcel
Oct 15, 2020·Addiction·Roy RobertsonMagdalena Harris

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