Both membrane-bound and soluble forms of CD14 bind to gram-negative bacteria

European Journal of Immunology
R S JackC Schütt

Abstract

Tissue macrophages and their precursors-the blood monocytes-respond rapidly to a bacterial infection with the release of inflammatory mediators. These mediators are involved in the recruitment of phagocytic cells, principally neutrophils, from the blood to the site of infection. To initiate this process macrophages and monocytes must be able to detect the presence of bacteria in a reliable, but nevertheless nonspecific, fashion. It is thought that this is achieved by means of receptors on the cell surface which recognize structures common to many different bacteria. One candidate for such a "pattern recognition element" is the cell surface glycoprotein CD14. CD14 has been shown to bind components of the Gram-positive cell wall and it also binds soluble lipopolysaccharide released from Gram-negative bacteria. In both cases the interaction with CD14 leads to an activation of the cell. Here we show that human peripheral blood monocytes can, in addition, bind intact Gram-negative bacteria in the presence of serum and this process involves CD14. When CD14 expression is induced on the myelomonocytic cell line U937 by treatment with vitamin D3 the cells concomittently acquire the capacity to bind bacteria. Furthermore, a non-monocytic...Continue Reading

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Citations

May 12, 1997·Journal of Immunological Methods·C SchüttS Witt
Dec 19, 2000·Infection and Immunity·H P JersmannA Ferrante
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J KluckenG Schmitz
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·N M IovineJ Weiss
Sep 18, 2009·FEMS Immunology and Medical Microbiology·Young Ae KangJae-Joon Yim
Mar 25, 2004·FEMS Immunology and Medical Microbiology·Eugenia PachecoMauricio A Arias
Oct 30, 2001·Acta Odontologica Scandinavica·K VidalA Donnet-Hughes
May 6, 1998·European Journal of Clinical Investigation·F StelterC Schütt
Nov 1, 1996·European Journal of Immunology·T TakakuwaM A Freudenberg
Aug 27, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RothenbacherH Brenner
Jul 7, 1998·The Journal of Experimental Medicine·V W ChanA Tarakhovsky
Aug 17, 1999·The Journal of Experimental Medicine·T VasselonP A Detmers
Sep 12, 1997·The Journal of Biological Chemistry·R I Tapping, P S Tobias
May 3, 2003·FEMS Immunology and Medical Microbiology·Homayoun ShamsPeter F Barnes
Jan 21, 2009·Immunology and Cell Biology·Miguel Angel RicoDaniel López
Dec 28, 2017·PloS One·Magdalena DruszczynskaWieslawa Rudnicka
Jan 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manuella LévêqueCorinne Martin-Chouly
Apr 20, 2011·Periodontology 2000·Lijian Jin
Dec 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stacy L KelleyRichard I Tapping
Mar 13, 2013·The Journal of Infectious Diseases·Zahra ToossiChristina S Hirsch
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K J MooreM W Freeman

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