Both sarcopenia and frailty determine suitability of patients for liver transplantation-A systematic review and meta-analysis of the literature

Clinical Transplantation
Judith KahnPeter Schemmer

Abstract

Liver grafts are allocated based on both urgency and utility. Due to a tremendous shortage of suitable organs for liver transplantation (LT), a careful selection of suitable recipients is of utmost importance. While the sickest first principle for organ allocation based on MELD score goes along with poor utility, other parameters reflecting the general health condition like frailty and sarcopenia might be essential to detect suitable patients for the waiting list. Thus, this study was designed to evaluate both frailty and sarcopenia in LT. A systematic review of the literature on sarcopenia and frailty measurements in liver transplant recipients was performed. Thirteen of 238 studies were selected for full paper review. Six of the studies investigating the impact of frailty on waitlist mortality were subjected to a meta-analysis. Despite the different methodologies to assess sarcopenia, reports showed that sarcopenia was highly related to waitlist mortality with a sum of all that highly favored negative outcome in case of sarcopenia. The existing literature clearly underlines that frailty and sarcopenia are important to determine in LT candidates. One unique index for transplant candidates reflecting frailty should be developed...Continue Reading

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Citations

Jul 18, 2019·Digestive Diseases and Sciences·Naga Swetha SamjiSanjaya K Satapathy
Dec 22, 2019·Journal of Cachexia, Sarcopenia and Muscle·Il-Young JangDae Hyun Kim
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Apr 28, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Samir Abu-Gazala, Peter L Abt

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