Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus.

Neuropharmacology
Q PeiM Fillenz

Abstract

The effects of benzodiazepine- and GABAA-receptor agonists and antagonists on the release and metabolism of 5-HT were measured in the ventral hippocampus of freely moving rats using microdialysis. Systemic injections of the benzodiazepine agonists, flurazepam and diazepam reduced the levels of 5-HT while the partial inverse agonist, FG 7142 (N-methyl-beta-carboline-3-carboxamide), had no effect. Local perfusion of flurazepam through the dialysis probe also decreased the release of 5-HT in the ventral hippocampus, an effect which was completely blocked by the benzodiazepine antagonist, Ro15-1788 (flumazenil). Local application of the GABAA agonist muscimol had no effect on the release of 5-HT, while the antagonist picrotoxin, administered locally, caused a 4-fold enhancement of release of 5-HT. Picrotoxin also resulted in a complete block of the inhibitory effect of flurazepam on release of 5-HT. None of these drugs caused significant changes in the levels of the metabolite of 5-HT, 5-hydroxyindoleacetic acid (5-HIAA) in the ventral hippocampus. These results suggest that the inhibitory effect of flurazepam on the release of 5-HT is mediated by benzodiazepine/GABAA receptors in the hippocampus and that GABA exerts a tonic inhibi...Continue Reading

References

May 15, 1978·European Journal of Pharmacology·D W Gallager
Jan 1, 1979·Annual Review of Pharmacology and Toxicology·E Costa, A Guidotti
May 1, 1979·European Journal of Pharmacology·A Saner, A Pletscher
Apr 21, 1977·Nature·R F Squires, C Brastrup
Aug 17, 1987·Life Sciences·T SharpU Ungerstedt
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel
Jul 1, 1981·Journal of Neurochemistry·R W Olsen
Oct 1, 1982·Neuropharmacology·M E TrulsonC J Frederickson
Jan 1, 1983·Advances in Biochemical Psychopharmacology·C BraestrupT Honoré
Nov 7, 1980·European Journal of Pharmacology·D J Balfour

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Citations

Jan 1, 1990·Journal of Neural Transmission. General Section·A LecciA Meli
Jul 21, 1992·European Journal of Pharmacology·N M BarnesR J Naylor
Jan 1, 1992·Pharmacology & Therapeutics·J A Pratt
Sep 1, 1990·Journal of Neuroscience Methods·M G BoutelleM Fillenz
May 1, 1990·Trends in Pharmacological Sciences·G Curzon, G A Kennett
Jul 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·L LimaE Trejo
May 7, 1998·European Journal of Pharmacology·M MatsumotoH Saito
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·B BertA Rex
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·J GeR J Naylor
Jan 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas I F H CremersBen H C Westerink
Dec 24, 1997·Australian and New Zealand Journal of Medicine·D Grounds
Dec 24, 1997·Australian and New Zealand Journal of Medicine·H Butzkueven
Mar 1, 2011·Trends in Neurosciences·Kelly R TanChristian Lüscher
Jul 9, 2008·Neuroscience Letters·Zeng-You YeJiang-Ning Zhou
Aug 9, 2005·Neuroscience Letters·Danielle Silveira MacêdoFrancisca Cléa Florenço de Sousa
Jan 6, 2010·The International Journal of Neuropsychopharmacology·Thomas I F H CremersBen H C Westerink

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