Both taurine and albumin support mouse sperm motility and fertilizing ability in vitro but there is no obligatory requirement for taurine

Journal of Reproduction and Fertility
L R Fraser

Abstract

When mouse spermatozoa were washed immediately upon release from the epididymis, preincubated for up to 120 min in PVA-containing, albumin-free medium and assessed for their ability to fertilize cumulus-intact eggs in vitro, they were poorly fertile in comparison with their unwashed counterparts in the same medium. Fertilizing ability could be significantly improved by introducing taurine or albumin or by washing a second time at the end of preincubation. The most effective treatment was provided by the continuous presence of low concentrations (0.05-0.1 mg/ml) of BSA, similar to the amount of albumin detected in the supernatants removed during washing. There was no evidence that acrosome loss was inhibited by washing; rather, it was enhanced by the removal of a surface component which inhibits the acrosome reaction. The presence of taurine did not further increase this response. Motility, reduced in washed suspensions, was improved by the presence of taurine or albumin and experimental results suggest that this was a major factor in the improvement of fertilizing ability after introduction of these compounds. Although taurine, hypotaurine and albumin were all found in the sperm washings and thus would be present in unwashed, f...Continue Reading

Citations

Oct 28, 2005·Histochemistry and Cell Biology·Jian Hua LiSheng Cui
Nov 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hamdy A A Aly, Rasha M Khafagy
Aug 21, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M V LoboR M del Río
Feb 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M V LoboR M del Río
Apr 1, 2018·The FEBS Journal·Atsushi AsanoAlexander J Travis

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