PMID: 9444983Jan 28, 1998Paper

Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathway

Journal of Virology
K W MuszynskiS K Ruscetti

Abstract

The erythroleukemia-inducing Friend spleen focus-forming virus (SFFV) encodes a unique envelope glycoprotein which allows erythroid cells to proliferate and differentiate in the absence of erythropoietin (Epo). In an attempt to understand how the virus causes Epo independence, we have been studying signal transduction pathways activated by Epo to determine if SFFV exerts its biological effects by constitutively activating any of these pathways in the absence of Epo. We previously demonstrated that Stat proteins, the downstream components of the Epo-induced Jak-Stat pathway, are constitutively activated in SFFV-infected cells. In this study, we demonstrate that SFFV also activates Raf-1, MEK and mitogen-activated protein (MAP) kinase, the downstream components of the Raf-1/MAP kinase pathway. This pathway was activated in cells infected with the polycythemia-inducing strain of SFFV, which induces both proliferation and differentiation of erythroid cells in the absence of Epo, as well as in cells infected with the anemia-inducing strain of the virus, which still require Epo for differentiation. Inhibition of Raf-1 by using antisense oligonucleotides led to a partial inhibition of the Epo-independent proliferation of SFFV-infected...Continue Reading

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Citations

Aug 30, 2008·Reviews in Medical Virology·Naoyoshi MaedaYasunobu Yoshikai
Oct 29, 2011·International Journal of Cancer. Journal International Du Cancer·Daigo UmeharaKazuo Nishigaki
Nov 20, 2002·The Journal of Experimental Medicine·Andrea KolbusManuela Baccarini
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·S K Ruscetti

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