Bothrops jararaca venom (BjV) induces differential leukocyte accumulation in mice genetically selected for acute inflammatory reaction: the role of host genetic background on expression of adhesion molecules and release of endogenous mediators

Toxicon : Official Journal of the International Society on Toxinology
Adriana S CarneiroNancy Starobinas

Abstract

The dynamics of the local inflammatory events induced by Bothrops jararaca venom (BjV) inoculation in footpad of mice genetically selected for maximal (AIRmax) and minimal (AIRmin) acute inflammatory reactivity (AIR) was investigated. The BjV injection induced a marked inflammatory cell infiltrate with predominance of neutrophils, with increased blood cell numbers before its accumulation, suggesting a stimulatory action of BjV on mechanisms of cell mobilization from bone marrow. The process of cell migration is regulated by different cell-adhesion molecules (CAM). Our results showed that neutrophil cells from both lines had the same pattern of response concerning CAMs expression, presenting the involvement of l-selectin, Mac-1 and PECAM-1 adhesion molecules in BjV-induced neutrophil accumulation. The effect of BjV on the release of pro-inflammatory cytokines and chemokines related with cellular migration was also studied and IL-1beta, IL-6, TNF-alpha and MIP-2 levels could be detected after venom injection. The AIRmax mice were shown to be more responsive than AIRmin with respect to leukocyte influx, expression of MIP-2 and release of IL-1beta and IL-6. These results demonstrate the importance of host genetic background in the ...Continue Reading

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Citations

Sep 11, 2014·Advances in Wound Care·Tatiane CanhameroMarcelo De Franco
Nov 10, 2012·The Journal of Surgical Research·Yilin ZhaoHenrik Thorlacius
Mar 6, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M F Dias-NetipanyiS Elifio-Esposito
Feb 19, 2013·Toxicon : Official Journal of the International Society on Toxinology·Fernando Chagas Patrão-NetoPaulo A Melo
Dec 1, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Rafhaella C A CedroSuely V Sampaio

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