Botox produces functional weakness in non-injected muscles adjacent to the target muscle

Journal of Biomechanics
M YaraskavitchWalter Herzog

Abstract

Botulinum type-A (BTX-A) neurotoxin exerts a paralytic effect on muscles and is used increasingly to treat a variety of muscle spasticity disorders. While its pathogenesis for muscle-induced weakness has been well elucidated, the functional effects of BTX-A administration are incomplete. Specifically, weakness as a function of muscle length and stimulation frequency has only been investigated qualitatively in a few muscles and the possible effect of the toxin on non-target muscles, although considered possible based on laboratory experiments, has not been studied widely and the functional implications remain unknown. Therefore, the purpose of this study was to measure the functional implications of BTX-A on force production and possible weakness of a target muscle and a non-injected neighbouring muscle. The cat soleus was chosen as the target muscle and was injected with 3.2-3.5U of BTX-A/kg in one hind limb, while the soleus of the other hind limb served as a non-injected control. Force-length properties within and exceeding the functional range of motion were determined at frequencies of stimulation of 10, 30 and 50Hz. Force-length properties of the adjacent non-injected plantaris were also determined in the experimental and ...Continue Reading

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Citations

Oct 23, 2010·Calcified Tissue International·Sarah L ManskeRonald F Zernicke
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Aug 21, 2013·Journal of Biomechanics·Rafael FortunaWalter Herzog
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Sep 11, 2010·Journal of Biomechanics·Rafael FortunaWalter Herzog

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