Botulinum A toxin intravesical injection in patients with painful bladder syndrome: 1-year followup

The Journal of Urology
Antonella GiannantoniEttore Mearini

Abstract

We evaluated the 1-year efficacy and tolerability of botulinum A toxin intravesically injected in patients with painful bladder symptoms associated with increased urinary frequency, refractory to conventional treatments. Three men and 12 women were prospectively included in the study. Under short general anesthesia the patients were given injections of 200 U commercially available botulinum A toxin diluted in 20 ml 0.9% NaCl. Injections were performed submucosally in the bladder trigone and lateral walls under cystoscopic guidance. A voiding chart and the visual analog scale for pain were used, and urodynamics were performed before treatment, and 1, 3, 5 and 12 months later. Overall 13 patients (86.6%) reported subjective improvement at the 1 and 3-month followups. The mean visual analog scale score, and daytime and nighttime urinary frequency were significantly decreased (p <0.05, <0.01 and <0.05, respectively). At the 5-month followup the beneficial effects persisted in 26.6% of cases but increased daytime and nighttime urinary frequency, and an increased visual analog scale score were observed compared to baseline. At 12 months after treatment pain recurred in all patients. Nine patients complained of dysuria 1 month after t...Continue Reading

References

Oct 1, 1992·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·K Zilles
Oct 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S T YuenS Y Leung
Feb 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·M J WelchK A Foster
Aug 18, 2000·Journal of Pain and Symptom Management·J WisselW Poewe
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Jul 12, 2002·American Journal of Clinical Pathology·Arpad Szallasi
Feb 25, 2003·Urological Research·Selahittin CayanErcüment Ulusoy
Jul 23, 2003·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bahman JabbariMarc P Difazio
Mar 18, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Giuseppe BrisindaAlberto Albanese
Apr 7, 2004·The Journal of Biological Chemistry·Cruz Morenilla-PalaoAntonio Ferrer-Montiel
May 6, 2004·The Journal of Urology·Christopher P Smith, Michael B Chancellor
Nov 10, 2004·Urology·Christopher P SmithMichael B Chancellor
Nov 23, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A B WardA Berardelli

❮ Previous
Next ❯

Citations

Jun 20, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Eleni G MourtzoukouMatthew E Falagas
Jan 25, 2012·International Urogynecology Journal·Tilemachos KavvadiasBernhard Schuessler
Jun 7, 2011·International Urology and Nephrology·Prashanth KanagarajahAngelo E Gousse
Apr 29, 2010·Current Pain and Headache Reports·Isabel C GreenPaul J Christo
Aug 16, 2008·Current Urology Reports·Abhishek Seth, Joel M H Teichman
May 7, 2010·Current Urology Reports·Henry P GottschRichard E Berger
Sep 12, 2012·Current Urology Reports·Christopher S Elliott, Christopher K Payne
Jul 19, 2008·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Mikel Gray
Jun 4, 2008·Current Opinion in Urology·Ann T Hanna-Mitchell, Lori A Birder
Apr 23, 2014·Expert Opinion on Investigational Drugs·Athanasios Dellis, Athanasios G Papatsoris
Sep 17, 2011·European Urology·Antonella GiannantoniJean Jacques Wyndaele
Jun 23, 2009·The Journal of Urology·Yao-Chi ChuangMichael B Chancellor
Nov 21, 2008·The Journal of Urology·Luke Harper
Jul 1, 2010·Neurourology and Urodynamics·Henry P GottschRichard E Berger
May 3, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·André Santos-SilvaFrancisco Cruz
Mar 21, 2012·Neurourology and Urodynamics·Philip HannoMichel Pontari
Apr 1, 2010·BJU International·Yao-Chi ChuangMichael B Chancellor
Aug 16, 2013·Neurourology and Urodynamics·Eleftheria L Chrysanthopoulou, Stergios K Doumouchtsis
Jun 5, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshiyuki AkiyamaYukio Homma
Aug 12, 2015·Nature Reviews. Urology·Yuan-Hong JiangHann-Chorng Kuo
Jan 28, 2015·The Journal of Urology·Alan J Wein
Mar 10, 2009·Toxicon : Official Journal of the International Society on Toxinology·Christopher P Smith
Dec 10, 2016·BJOG : an International Journal of Obstetrics and Gynaecology
Jul 12, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Hung-Jen WangYao-Chi Chuang
Jun 25, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaUNKNOWN Interstitial cystitis guideline committee
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Dimitrios-Anestis Moutzouris, Matthew E Falagas
Nov 28, 2012·Nature Reviews. Urology·Jochen Neuhaus, Thilo Schwalenberg
May 16, 2009·Current Opinion in Urology·Carlos Martins da Silva, Francisco Cruz
May 11, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Yue-Chen Kuo, Hann-Chorng Kuo
Sep 21, 2013·Current Opinion in Urology·Andrew RussellArun Sahai
May 9, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Jia-Fong JhangHann-Chorng Kuo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.