Botulinum C2 toxin treatment increases the G-actin pool in intact chicken cells: a model for the cytopathic action of actin-ADP-ribosylating toxins

Toxicon : Official Journal of the International Society on Toxinology
K AktoriesM Bärmann

Abstract

Botulinum C2 toxin ADP-ribosylates actin in intact chicken embryo cells in a concentration-dependent manner. This effect correlates with an enhancement in the inhibitory potency of the respective cell lysates on DNAse I activity, indicating an increase in the cellular G-actin content of toxin-treated cells. The data support our view, that ADP-ribosylation of cellular actin with subsequent depolymerization of cytoskeleton-associated F-actin to monomeric G-actin is involved in the cytotoxic effects of botulinum C2 toxin. A model of the cytopathic action of actin-ADP-ribosylating toxins is presented.

References

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Citations

Sep 1, 1994·Molecular and Cellular Biochemistry·K Aktories
Oct 1, 1992·Molecular Microbiology·K Aktories, A Wegner
Sep 9, 2004·Microbiology and Molecular Biology Reviews : MMBR·Holger BarthBradley G Stiles
Sep 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·K H ReunerN Katz
May 17, 2006·Anaerobe·Klaus Aktories, Holger Barth
Apr 30, 1999·Emerging Infectious Diseases·C K SchmittA D O'Brien
Jan 8, 2013·Human Vaccines & Immunotherapeutics·Yajun TanJunzhi Wang

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