Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study.

Journal of Neural Transmission
Paula Ruth L SiongcoDirk Dressler

Abstract

Apart from the known efficacy of Botulinum Neurotoxin Type A (BoNT/A) in hyperactive striated and smooth muscles, different pain states have become potential targets of toxin effects. This present study determined the comparative toxin effectiveness in pain reduction among those patients injected with BoNT/A in muscle-based and in non-muscle-based conditions. Randomized controlled trials (RCTs) on the effect of BoNT/A on selected pain conditions were included. The conditions were spasticity and dystonia for muscle-based pain. For non-muscle-based pain, conditions included were painful diabetic neuropathy (PDN), post-herpetic neuralgia (PHN), trigeminal neuralgia (TN), complex regional pain syndrome (CRPS), and spinal cord injury (SCI). In view of possibly differing pathophysiology, myofascial pain, temporomandibular joint (TMJ), other joint or tendon pains, cervicogenic and lumbar pains, migraine and visceral pain syndromes were excluded. Standardized mean difference was used as the effect measure and computed with STATA. 25 RCTs were analyzed. Pooled estimates showed significantly lower pain score in the Treatment group (z = 5.23, p < 0.01, 95% CI = - 0.75, - 0.34). Subgroup analyses showed that BoNT/A significantly reduced bo...Continue Reading

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Citations

Oct 31, 2020·Journal of Neural Transmission·Dirk DresslerRaymond L Rosales
Dec 10, 2020·The International Journal of Neuroscience·Michał MarciniecKonrad Rejdak
Oct 26, 2020·Journal of Neural Transmission·Lynley V BradnamAlana McCambridge
Jun 25, 2021·Pain and Therapy·Samantha-Su TaylorOmar Viswanath
Jul 29, 2021·Clinical Parkinsonism & Related Disorders·Richard M TroschSavary Om
Sep 28, 2021·Expert Review of Neurotherapeutics·Raymond L RosalesRichard M Trosch

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