Botulinum toxin A: a 9-month clinical and 3D in vivo profilometric crow's feet wrinkle formation study

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology
Jean Luc LevyElisabeth Jouve

Abstract

The objective of this study was to determine the duration of the effects of a defined dose of BTX-A on crow's feet formation wrinkles. Twenty-five patients each received one injection of 12 units of BTX-A in the orbicularis oculi muscle on both sides of the face. The results were evaluated at 3, 6 and 9 months. Standardized photographs were taken of the wrinkle formations at rest at each step of the 9-month period following the treatment, and the wrinkles were then rated on photographs by blinded observers. Three-dimensional (3D) in vivo profilometry was also used to quantify the degree of improvement. Both the self-assessments by the patients themselves and the objective assessments of the 3D profilometry study provided similar results, but the independent observer assessment results were slightly more optimistic. There was a statistically significant difference observed between baseline and the evaluations at both 3 and 6 months. BTX-A is a safe and effective method for treating crow's feet wrinkles. In both the observer assessment and the 3D skin profilometric assessment, a clear improvement was shown at 6 months.

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Citations

Jul 14, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·J L LevyE Jouve
May 23, 2007·Expert Opinion on Pharmacotherapy·Koenraad L V De Boulle
Nov 26, 2013·Dermatologic Clinics·Andrew DorizasNeil S Sadick
Mar 1, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maurizio CavalliniMassimo Signorini
Jan 10, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Myeongseob KoKwangtaek Kim
Jun 4, 2008·Plastic and Reconstructive Surgery·Arnold W KleinNicholas J Lowe
Apr 8, 2010·American Journal of Clinical Dermatology·Timothy Corcoran Flynn
Aug 25, 2010·Annals of Plastic Surgery·Olivier A BranfordAdriaan O Grobbelaar
Jul 19, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alastair CarruthersMitchell F Brin
Oct 7, 2015·Plastic and Reconstructive Surgery·Michael S Gart, Karol A Gutowski
Aug 29, 2020·Journal of Cosmetic Dermatology·Marina LandauFiras Al-Niaimi
Apr 26, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Leslie BaumannConor J Gallagher
Oct 10, 2015·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·K Kim
Aug 9, 2017·Medical & Biological Engineering & Computing·Kwangtaek Kim
Oct 15, 2020·Aesthetic Plastic Surgery·Nitin SethiEqram Rahman

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