Botulinum toxin A for the treatment of cervical dystonia

Expert Opinion on Pharmacotherapy
Theresa A ZesiewiczRobert A Hauser

Abstract

Idiopathic cervical dystonia (ICD) is the most common adult-onset focal dystonia. It is characterised by relatively sustained, involuntary contractions of neck muscles. Injections of botulinum toxin (BTX)-A are safe and effective for the treatment of ICD, and have substantially improved its treatment. BTX-A is manufactured by Allergan Pharmaceuticals in the US and Ireland, and is distributed as Botox. In Europe, BTX-A is manufactured and distributed by Ipsen Pharmaceuticals as Dysport. Success rates for BTX-A injections for ICD ranges 64-90%, with 76-93% of injected patients experiencing pain reduction. Side effects are generally mild and include dysphagia and neck weakness.

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Citations

Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Stefania Lalli, Alberto Albanese
Apr 29, 2015·Toxicon : Official Journal of the International Society on Toxinology·Jiubiao GuoSheng Chen
May 18, 2005·Archives of Facial Plastic Surgery·Jeffrey H Spiegel

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