Botulinum toxin-A injections vs radiotherapy for drooling in ALS

Acta Neurologica Scandinavica
J G WeikampJohanna G Kalf

Abstract

Botulinum neurotoxin (BoNT) injections in the salivary glands and radiotherapy (RT) on these glands are commonly used to alleviate severe drooling in patients with amyotrophic lateral sclerosis (ALS). This study compares BoNT type A with RT based on patient-rated evaluations. A prospective randomized controlled pilot study to compare RT (n = 10; on the parotid and the posterior part of the submandibular glands) with BoNT-A treatment (n = 10; in the parotid glands only, because of the risk of increasing oropharyngeal weakness) in patients with ALS. The primary outcome was the drooling status (burden of drooling), and our secondary interests were the degree of salivation, global change of drooling after treatment, and level of satisfaction with the treatment and negative experiences. There were no statistically significant between-treatment differences for the drooling status after treatment. Only at twelve weeks more saliva reduction was achieved by RT (P = 0.02). Patients treated with RT also described more transient negative experiences (like pain in mandible) directly after treatment. Subgroup analysis showed that patients with very severe dysphagia (no oral intake) were less satisfied and experienced a lower global change of...Continue Reading

References

Jan 1, 1989·Neuroepidemiology·A D HillelN Konikow
Dec 28, 1999·Brain : a Journal of Neurology·C ErtekinB Uludag
Jun 23, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·R GiessK V Toyka
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Jan 5, 2002·The Journal of Otolaryngology·M HarrimanB Lentle
Apr 24, 2002·Neurology·Lukas J A Stalpers, Elizabeth C Moser
Mar 18, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Markus Naumann, Wolfgang Jost
Oct 26, 2005·Neurology·J P Van den BergL H Van den Berg
Jun 30, 2006·Parkinsonism & Related Disorders·Maria Fiorella ContarinoAnna Rita Bentivoglio
Apr 25, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Maud MaessenLeonard H van den Berg
Oct 19, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E NeppelbergO-B Tysnes
Feb 28, 2008·American Journal of Physical Medicine & Rehabilitation·Jan-Willem G MeijerMachiel J Zwarts
Jan 16, 2009·Muscle & Nerve·Carlayne E JacksonUNKNOWN Muscle Study Group
Feb 19, 2010·Developmental Medicine and Child Neurology·Corrie E ErasmusPeter H Jongerius
Mar 19, 2011·Journal of Palliative Medicine·Nathalie GuyPierre Clavelou
May 11, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Johnathan Cooper-KnockPamela Shaw
Sep 15, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· Markus Weber
Apr 11, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Nina SquiresJohn Rowson
Nov 9, 2012·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Maya Abdelnour-MalletPierre François Pradat
May 8, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Esther V HobsonChristopher J McDermott
May 15, 2013·Acta Neurologica Scandinavica·G RuoppoloM Inghilleri
Aug 30, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Morten Gersel StokholmOle Jakob Vilholm
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Avi AssoulinePierre-François Pradat
Sep 17, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Alexander J McGeachanChristopher J McDermott

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Citations

Apr 27, 2016·Clinical Oral Investigations·Janne Tiigimäe-SaarTiia Tamme
Mar 18, 2017·The Laryngoscope·Kayhan OzturkAyse Olmez
Oct 6, 2017·Nature Reviews. Disease Primers·Orla HardimanLeonard H van den Berg
Feb 15, 2020·Toxins·Maria-Angeles Serrera-FigalloJose-Luis Gutierrez-Perez
Apr 12, 2019·Journal of Neural Transmission·Armin SteffenOrlando Guntinas-Lichius
May 31, 2018·Toxins·Javier Martínez-PolesAraceli Alonso-Canovas
Sep 23, 2019·Neurology and Therapy·Wolfgang H JostGanesh Bavikatte
Dec 11, 2019·Therapeutic Advances in Neurological Disorders·Francesca MorganteBiju Mohamed
Apr 30, 2021·Laryngo- rhino- otologie·Armin Steffen, Saskia Rohrbach-Volland

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