Botulinum toxin as treatment for focal dystonia: a systematic review of the pharmaco-therapeutic and pharmaco-economic value.

Journal of Neurology
E ZoonsM A Tijssen

Abstract

Focal dystonia is a common, invalidating neurologic condition characterized by involuntary, sustained muscle contractions causing twisting movements and abnormal postures in one body part. Currently, botulinum toxin is the treatment of first choice. We performed a systematic review towards the pharmaco-therapeutic and pharmaco-economic value of botulinum toxin as treatment for focal dystonia, which yielded the following results. Botulinum toxin is the most effective treatment for reducing dystonic symptoms measured with dystonia-specific and general questionnaires, and pain in patients with focal dystonia. Seventy-one percent of patients with cervical dystonia had a reduction in neck pain compared to 12 % in placebo groups. Adverse events occur in 58 % of patients during treatment with botulinum toxin compared to 46 % treated with placebo. Especially dry mouth, neck weakness, dysphagia, and voice changes are common. Adverse events are usually mild and self-limiting. Health-related quality of life, measured with the SF-36 is 20-50 points lower in patients with focal dystonia compared to controls and the effect of botulinum toxin on health-related quality of life is unclear. Botulinum toxin treatment is expensive because the drug...Continue Reading

References

Jul 1, 1991·Journal of the American Geriatrics Society·M WeinbergerJ R Feussner
Apr 15, 1993·Annals of Internal Medicine·G H GuyattD L Patrick
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·C M GudexP Duffey
Nov 3, 1997·PharmacoEconomics·R C DodelW H Oertel
Oct 6, 2000·Clinical Neuropharmacology·C Brefel-CourbonM Lapeyre-Mestre
Dec 29, 2000·Journal of Neurology·UNKNOWN Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group
Jan 12, 2001·Acta Neurologica Scandinavica·O TuchaK W Lange
Jul 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·R HilkerJ Rudolf
Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·Y Ben-ShlomoUNKNOWN ESDE collaborative group
Jul 26, 2002·Journal of Neurology·J MüllerUNKNOWN Austrian Botulinum Toxin and Dystonia Study Group
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Laura CamfieldUNKNOWN Epidemiological Study of Dystonia in Europe Collaborative Group
Nov 12, 2003·Neurology·Khanh-Dung LeEspen Dietrichs
Jul 17, 2004·Seminars in Neurology·A Gordon Smith
Jun 21, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sonja von CampenhausenRichard Dodel
Aug 23, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Inger Marie SkogseidEmilia Kerty
Aug 25, 2006·The New England Journal of Medicine·Daniel Tarsy, David K Simon
Dec 23, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·J J M KruisdijkJ D Speelman
Aug 22, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I M SkogseidE Kerty
Sep 11, 2007·Clinical Therapeutics·Mary Ann ChapmanP David Charles
Mar 8, 2008·Parkinsonism & Related Disorders·Daniel TruongUNKNOWN Dysport Benign Essential Blepharospasm Study Group
Nov 11, 2008·Clinical Neurology and Neurosurgery·Tatjana PekmezovicVladimir S Kostic
May 15, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Eric S MolhoStewart A Factor
Aug 8, 2009·Parkinsonism & Related Disorders·Kirsti K MartikainenReijo J Marttila
Nov 4, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Lizheng ShiJim Smeeding
Feb 23, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Elan D Louis, Joaquim J Ferreira
Jul 16, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J K Krauss
Jul 9, 2010·Current Opinion in Neurology·Marie-Laure WelterMarie Vidailhet
Aug 24, 2011·The Annals of Otology, Rhinology, and Laryngology·Kristine TannerMarshall E Smith
Sep 13, 2011·International Review of Neurobiology·John YianniTipu Z Aziz

❮ Previous
Next ❯

Citations

Jan 29, 2008·BMC Musculoskeletal Disorders·Benedict Martin Wand, Neil Edward O'Connell
Oct 22, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mary Ann Thenganatt, Joseph Jankovic
Jun 19, 2013·Brain : a Journal of Neurology·Gavin CharlesworthNicholas W Wood
Aug 22, 2014·Case Reports in Neurological Medicine·Siria Di MartinoCarmelo Chisari
Oct 16, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Christian PedemonteDiego Lazo
Aug 4, 2015·Annals of Physical and Rehabilitation Medicine·A SchnitzlerF Genet
Aug 29, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Annie Killoran, Kevin M Biglan
Apr 17, 2015·Journal of Neurology·Alberto AlbaneseCharalampos Tzoulis
Aug 25, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto AlbaneseDaniela Calandrella
Jul 26, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C C S DelnoozB P C van de Warrenburg
Jun 28, 2017·Rinshō shinkeigaku = Clinical neurology·Yusaku Nakamura
Mar 6, 2018·Neurology India·Priyanka Tater, Sanjay Pandey
Sep 14, 2018·Clinical Drug Investigation·Alessio BaricichMarco Invernizzi
Jan 30, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rashid Kazerooni, Christine Broadhead
Jun 26, 2015·Current Opinion in Neurology·Hyder A JinnahWendy R Galpern
Aug 14, 2019·PM & R : the Journal of Injury, Function, and Rehabilitation·Steven KirshblumAmanda Botticello
Dec 13, 2017·The Cochrane Database of Systematic Reviews·Mafalda CastelãoJoão Costa
May 14, 2016·The Cochrane Database of Systematic Reviews·Raquel E MarquesJoão Costa
Jul 28, 2020·Clinical & Experimental Ophthalmology·John C BladenRaman Malhotra
Sep 22, 2018·Nature Reviews. Disease Primers·Bettina BalintKailash P Bhatia
Nov 13, 2020·The Cochrane Database of Systematic Reviews·Filipe B RodriguesJoão Costa
Jan 25, 2019·Neurobiology of Disease·Alexey SedovAasef G Shaikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.