Botulinum toxin for overactive bladder

Der Urologe. Ausg. A
B K ZiegelmüllerRicarda Bauer

Abstract

Idiopathic overactive bladder (OAB) is defined as a symptom complex characterized by urinary urgency with or without urinary incontinence, nycturia and increased frequency of micturition without the presence of an infection or other pathological conditions, especially a neurological disease. It is a diagnosis by exclusion. If conservative treatment with behavioral therapy and pelvic floor muscle training alone is not successful, pharmaceutical treatment is recommended according to the OAB staged treatment. For treatment refractory OAB, intravesical injection of onabotulinum toxin A is recommended according to the current guidelines (recommendation level A). The approved dose is 100 U botulinum toxin and is transurethrally injected into the detrusor muscle. The treatment effect lasts on average for 6-9 months and injections can be repeated without limitations. Due to the low rate of complications, the good success rate and the low invasiveness, botulinum toxin offers a good treatment option for treatment refractory OAB.

References

Sep 17, 2005·Neurourology and Urodynamics·Erin T BirdK Scott Coffield
Feb 21, 2006·Physical Review Letters·S S AdlerUNKNOWN PHENIX Collaboration
Mar 14, 2008·BJU International·Karin S CoyneIan Milsom
Oct 22, 2008·The Journal of Urology·Wesley M WhiteFrederick A Klein
Jan 31, 2009·The New England Journal of Medicine·Leslee L SubakUNKNOWN PRIDE Investigators
Nov 17, 2009·BJU International·Joshua S BennerLinda Brubaker
Mar 23, 2011·The Journal of Urology·Ying H JuraFrancine Grodstein

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