PMID: 8961295Nov 15, 1996Paper

Botulinum toxin induces nitric oxide synthase activity in motoneurons

Neuroscience Letters
R Mariotti, M Bentivoglio

Abstract

Intramuscular injections of botulinum toxin A were made into the snout of 3-month- and 3-week-old rats, resulting in transient paralysis of the facial muscles. Nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemistry, which is a marker of nitric oxide synthase activity in fixed tissue and, in particular, in injured motoneurons, was studied in the facial nucleus. At variance with control injections of saline, the histochemical staining was found to be induced in facial motoneurons after botulinum toxin injection. The occurrence and persistence of the histochemical positivity in facial motoneurons paralleled that of muscle paralysis. These findings indicate that the enzyme of synthesis of the free radical nitric oxide can be induced in motoneurons after a functional disconnection from the target, which spares the axon and is associated with cell survival.

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Citations

Nov 18, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·O M JonesN J Mc C Mortensen
Nov 27, 2007·Progress in Neurobiology·F FlorenzanoM Molinari
Jun 3, 2015·Toxins·Giuseppe BrisindaGiorgio Maria
Aug 2, 2006·Reviews in the Neurosciences·Bernardo Moreno-López, David González-Forero
Jul 2, 2002·Journal of Neurophysiology·Verónica AbudaraFrancisco R Morales
Jun 28, 2006·Gastroentérologie Clinique Et Biologique·Fady DanielPatrick Atienza

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