Botulinum toxin injection for the treatment of epiphora in lacrimal outflow obstruction

Eye
K ZiahosseiniR Malhotra

Abstract

To describe our experience with the use of botulinum toxin (BoNTA) for the symptomatic treatment of lacrimal outflow obstruction. We retrospectively reviewed the case notes of patients with epiphora due to lacrimal outflow obstruction who chose to have injections of botulinum toxin into the palpebral lobe of the lacrimal gland instead of surgery between 2009 and 2014. Epiphora was graded subjectively with Munk scores obtained before and after treatment as well as qualitative degree of improvement reported by the patients. Severity and duration of side effects were also noted. Seventeen patients (22 eyes, mean age 70.3, 4 males and 13 females) were identified. A mean of 3.5 (range; 1-10) injections of BoNTA (Botox, Allergan; 1.25-7.5 units) were given per eye. The mean interval between injections was 3.9 months (range 3-6). The mean Munk score (3.4, range 2-4) improved significantly after treatment to 1.6 (range: 0-3, P=0.0001 paired two-tailed t-test). Epiphora completely resolved in a fifth, improved by up to 60-90% in a half and only 'a little better' in a further fifth. Temporary bruising and diplopia (lasting 2 weeks) was reported in 12% (2/17). We report our outcomes for BoNTA to the palpebral lobe of the lacrimal gland in...Continue Reading

References

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Citations

Apr 21, 2018·Indian Journal of Ophthalmology·Purvasha NarangVikas Mittal
Jul 12, 2018·Current Opinion in Ophthalmology·Adel H Alsuhaibani, Shaikha Al Eid
May 9, 2018·Ophthalmic Plastic and Reconstructive Surgery·Christopher B SchulzSimon Rogers
Aug 3, 2017·International Ophthalmology·Swati SinghFriedrich Paulsen
Aug 17, 2021·Orbit·Johnathan JeffersVinay Aakalu
Oct 19, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Micheal A O'Rourke, Paul S Cannon

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