Botulinum toxin injection in the pediatric population with medically refractory neuropathic bladder

Journal of Pediatric Urology
M K KhanP P Reddy

Abstract

Botulinum toxin injection (BTI) has been advocated as a second line therapy in management of neuropathic bladder in pediatric population for refractory patients to conventional medical management such as anticholinergics. The purpose was to review the safety and efficacy of BTI in children with neuropathic bladder refractory to conservative non-surgical measures. We hypothesized that BTI would be an effective alternative to bladder augmentation in certain patients but not all. We retrospectively identified 22 patients with neuropathic bladder due to any condition who underwent urologic BTI at our hospital since 2010. Multiple clinicopathologic variables were examined including the following: demographics, use of anticholinergics, the presence of anticholinergic refractoriness or intolerance, dosage of BTI, urodynamic variables, and continence status. The mean patient age at time of BTI was 10 years with a follow up of 12 months. Indications for BTI were anti-cholinergic refractory (AR) urodynamic parameters and/or incontinence and anticholinergic intolerance (AI). Nearly all patients received 300 Units at BTI into detrusor. No complications occurred from BTI. Overall 54% had improved continence after the initial BTI whereas 45%...Continue Reading

References

May 6, 2004·The Journal of Urology·Christopher P Smith, Michael B Chancellor
Oct 20, 2007·The Journal of Urology·Khalid Fouda NeelAmenah Khatab
Jan 9, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Ulka B CampbellRich Barron

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Citations

Oct 18, 2016·Current Opinion in Urology·Jeroen R ScheepeLisette A 't Hoen
Sep 10, 2016·Current Bladder Dysfunction Reports·Renea M Sturm, Earl Y Cheng
Aug 15, 2018·World Journal of Urology·Jairam R EswaraMarc Cendron
Aug 23, 2018·Neurourology and Urodynamics·Christopher H FryKarl-Erik Andersson
Jan 5, 2021·Current Opinion in Urology·Hatim ThakerMin Dong

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