Botulinum toxin type A for neuropathic pain in patients with spinal cord injury

Annals of Neurology
Zee-A HanMyung Eun Chung

Abstract

To evaluate the analgesic effect of botulinum toxin type A (BTX-A) on patients with spinal cord injury-associated neuropathic pain. The effect of BTX-A on 40 patients with spinal cord injury-associated neuropathic pain was investigated using a randomized, double-blind, placebo-controlled design. A 1-time subcutaneous BTX-A (200U) injection was administered to the painful area. Visual analogue scale (VAS) scores (0-100mm), the Korean version of the short-form McGill Pain Questionnaire, and the World Health Organization WHOQOL-BREF quality of life assessment were evaluated prior to treatment and at 4 and 8 weeks after the injection. At 4 and 8 weeks after injection, the VAS score for pain was significantly reduced by 18.6 ± 16.8 and 21.3 ± 26.8, respectively, in the BTX-A group, whereas it was reduced by 2.6 ± 14.6 and 0.3 ± 19.5, respectively, in the placebo group. The pain relief was associated with preservation of motor or sensory function below the neurological level of injury. Among the responders in the BTX-A group, 55% and 45% reported pain relief of 20% or greater at 4 and 8 weeks, respectively, after the injection, whereas only 15% and 10% of the responders in the placebo group reported a similar level of pain relief. Im...Continue Reading

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Jul 6, 2017·Pharmaceuticals·Angela FaccendiniFranca Ferrari
Dec 13, 2017·Scandinavian Journal of Pain·Alice L HungTina L Doshi
Aug 25, 2017·Toxins·JungHyun Park, Hue Jung Park
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May 5, 2021·The European Journal of Neuroscience·Svenja KankowskiKirsten Haastert-Talini
Apr 13, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Clare CanavanBrona M Fullen

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