Botulinum toxin type a in the prophylactic treatment of transformed migraine in Taiwanese patients: a review of 30 consecutive cases

Journal of the Chinese Medical Association : JCMA
Yi-Chung LiuShuu-Jiun Wang

Abstract

Botulinum toxin type A (BoNT-A) for the treatment of patients with various forms of migraine has been studied, but there is a paucity of data regarding the use of BoNT-A in Asian headache patients. Our study was designed to evaluate the efficacy of BoNT-A in the treatment of transformed migraine (TM) in a population of Taiwanese patients. We retrospectively analyzed 30 patients who underwent BoNT-A treatment for TM from July 2003 to May 2004. Of 30 patients, 14 had palpable muscle tenderness (or tender points) in the pericranial region and 16 did not. All patients received injections into the corrugator, procerus, frontalis, and temporalis muscles (a total of 30 U), while a subset of TM patients with tender points (6 of 14 patients) also received injections to additional muscles based on a follow-the-tenderness approach (mean dose, 45 U). Twenty-seven of the 30 patients (90%) surveyed reported effective relief of their symptoms with BoNT-A treatment (at least a 50% reduction in the number of headache days or in headache intensity). The greatest reduction in headache days per month and headache intensity was found in TM patients with tender points who received a mean dose of 45 U compared to those who received fixed-site dosing ...Continue Reading

References

Feb 1, 1990·Neurology·J Jankovic, K Schwartz
Jun 28, 2000·Current Opinion in Neurology·S D Silberstein, R B Lipton
Nov 15, 2000·Cephalalgia : an International Journal of Headache·S J WangB C Shia
Feb 1, 2002·Nature Medicine·Hayrunnisa BolayMichael A Moskowitz
Feb 15, 2002·Cephalalgia : an International Journal of Headache·S R LuS J Wang
Jul 4, 2002·Current Pain and Headache Reports·Alexander Mauskop
Dec 23, 2003·Cephalalgia : an International Journal of Headache·W G OndoH S Derman
Sep 15, 2004·Neurology·Ninan T MathewTad Seifert
Sep 21, 2004·Cephalalgia : an International Journal of Headache·S EversA Frese
Jun 15, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Stewart A FactorPaul J Feustel
Jun 15, 2006·American Journal of Therapeutics·K S AnandKiran Bala

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Citations

May 12, 2010·Journal of the Chinese Medical Association : JCMA·Chia-Hung LinSen-Wei Tsai
Nov 26, 2008·The Journal of Headache and Pain·Sherif M HamdyRasha Hasan
Jul 8, 2011·Acta Neurologica Scandinavica. Supplementum·M LindeL J Stovner
Oct 15, 2013·The European Journal of Neuroscience·Sonu BhaskarHoushang Amiri
Jul 6, 2014·Headache·Signe B Munksgaard, Rigmor H Jensen

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