Botulinum Toxin Type A Injection for Cervical Dystonia in Adults with Dyskinetic Cerebral Palsy

Toxins
You Gyoung YiMoon Suk Bang

Abstract

We aimed to evaluate the efficacy and safety of injecting botulinum toxin A (BoNT-A) into the neck muscles to treat cervical dystonia (CD) in patients with dyskinetic cerebral palsy (CP). This was a randomized, double-blinded, placebo-controlled trial with cross-over design. We prospectively enrolled adults with dyskinetic CP who were over 20 years old and had been clinically diagnosed with CD for more than one year. The primary outcome measure was the change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) at four weeks from the baseline TWSTRS. Seventeen patients were initially enrolled, but one patient was excluded after the final evaluation because of a violation of the study protocol. At four weeks, the BoNT-A injections showed significant improvement in TWSTRS total scores compared to the saline injections (p = 0.0286 for ANCOVA). At 12 weeks, the BoNT-A injections resulted in greater improvements in TWSTRS total scores than the saline injections without statistical significance (p = 0.0783 for ANCOVA). Dysphagia occurred in three out of 16 patients: two after BoNT-A and one after saline. The dysphagia was transient and improved naturally within two weeks without any special treatment. BoNT-A injection for C...Continue Reading

References

Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·J ChanS Fahn
May 11, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Birgit HertingMarkus Naumann
Oct 19, 2004·Lancet Neurology·Giovanni DefazioAlfredo Berardelli
Jan 28, 2005·The Cochrane Database of Systematic Reviews·J CostaC Sampaio
Mar 1, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel TruongGeoffrey L Sheean
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Joaquim J FerreiraCristina Sampaio
Dec 17, 2008·Toxicon : Official Journal of the International Society on Toxinology·Joseph Jankovic
Dec 20, 2008·Journal of Korean Neurosurgical Society·Yong-Jeon LeeYoung-Sup Park
Apr 3, 2010·Parkinsonism & Related Disorders·Daniel TruongUNKNOWN Global Dysport Cervical Dystonia Study Group
Jul 19, 2011·Journal of the Neurological Sciences·Cynthia L ComellaUNKNOWN U.S. XEOMIN Cervical Dystonia Study Group
Feb 14, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Areej I ElkamilTorstein Vik
Nov 8, 2012·Spine·Takeo FuruyaKazuhisa Takahashi
Jan 11, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Gi-Hyeok Yang, Hyun Ho Jung
Jun 18, 2015·Patient Preference and Adherence·Reversa R Mills, Fernando L Pagan
Jun 20, 2015·Journal of the Neurological Sciences·Josef FinstererDaniel Truong
Sep 1, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph Jankovic
Sep 15, 2016·Journal of Neural Transmission·L Tatu, W H Jost
Oct 14, 2016·Frontiers in Neurology·Maria Fiorella ContarinoMarina A J Tijssen
Mar 14, 2017·Frontiers in Neurology·Maria Fiorella ContarinoMarina A J Tijssen
Apr 23, 2017·Journal of the Neurological Sciences·Richard M TroschCynthia L Comella
Jun 13, 2017·American Journal of Physical Medicine & Rehabilitation·Won Kee ChangMoon Suk Bang
Aug 18, 2017·Lancet Neurology·Elegast MonbaliuBernard Dan
Sep 6, 2017·Developmental Medicine and Child Neurology·Riccardo MassonGiovanni Baranello
Dec 13, 2017·The Cochrane Database of Systematic Reviews·Mafalda CastelãoJoão Costa
May 7, 2015·Movement Disorders Clinical Practice·Wolfgang H Jost, Laurent Tatu

❮ Previous
Next ❯

Citations

Jul 18, 2019·Annals of Rehabilitation Medicine·You Gyoung YiMoon Suk Bang
Aug 6, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Beom Suk KimJoon Shik Yoon
Jan 13, 2021·Toxins·Charenya Anandan, Joseph Jankovic

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01860196

Software Mentioned

SPSS
SAS

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.