Botulinum toxin type A therapy for blepharospasm.

The Cochrane Database of Systematic Reviews
Gonçalo S DuarteJoão Costa

Abstract

This is an update of a Cochrane Review first published in 2005. Blepharospasm is the second most common form of focal dystonia. It is a disabling disorder, characterised by chronic, intermittent or persistent, involuntary eyelid closure, due to spasmodic contractions of the orbicularis oculi muscles. Currently, botulinum toxin type A (BtA) is considered the first line of therapy for this condition. To compare the efficacy, safety, and tolerability of BtA versus placebo in people with blepharospasm. We searched Cochrane Movement Disorders' Trials Register, CENTRAL, MEDLINE, Embase, reference lists of included articles, and conference proceedings. We ran all elements of the search, with no language restrictions, in July 2020. Double-blind, parallel, randomised, placebo-controlled trials (RCTs) of BtA versus placebo in adults with blepharospasm. Two review authors independently assessed records, selected included studies, extracted data using a paper pro forma, and evaluated the risk of bias. We resolved disagreements by consensus, or by consulting a third review author. We performed meta-analyses using a random-effects model, for the comparison of BtA versus placebo, to estimate pooled effects and corresponding 95% confidence int...Continue Reading

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Citations

Jan 13, 2021·Toxins·Charenya Anandan, Joseph Jankovic
Apr 15, 2021·The Cochrane Database of Systematic Reviews·Filipe B RodriguesJoão Costa

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