Botulinum toxin types A, B and D inhibit catecholamine secretion from bovine adrenal medullary cells

FEBS Letters
D E Knight

Abstract

Evoked catecholamine secretion from cultured bovine adrenal medullary cells is inhibited by commercially available botulinum toxins - types A, B and D (10(4)-10(6) MLD/ml of culture medium). Basal secretion is also inhibited. The catecholamine content of such toxin-treated cells is larger than that of control cells and may in part be a result of the inhibition of basal release. The onset of action of botulinum toxin types A and D can be neutralised by their respective antisera. Concentrations of botulinum toxins A, B or D that inhibit secretion leave unaffected the 45Ca2+ influxes normally associated with secretion. These data provide further evidence to support the idea [(1985) Nature 317, 719-721] that botulinum toxins block secretion by acting downstream of the Ca2+ transient at or near the site of exocytosis.

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Citations

Jul 5, 2006·Der Schmerz·K R AokiW H Jost
Jun 9, 2007·Journal of Neural Transmission·K R Aoki
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·P MarxenH Bigalke
Jul 22, 1991·Biochimica Et Biophysica Acta·R D Burgoyne
Dec 24, 1997·Toxicon : Official Journal of the International Society on Toxinology·L B PearceA Gupta
Aug 28, 1998·Current Opinion in Cell Biology·C Montecucco
Nov 21, 1998·The European Journal of Neuroscience·A GilL M Gutiérrez
Jun 15, 1987·European Journal of Biochemistry·J Sanchez-PrietoD G Nicholls
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·M CriadoL M Gutiérrez
May 1, 1987·Bioscience Reports·D E Knight
Jan 2, 1989·FEBS Letters·G Ahnert-HilgerM Gratzl
Apr 4, 2000·Physiological Reviews·G SchiavoC Montecucco
Apr 29, 1987·Biochemical and Biophysical Research Communications·T TanakaO Hayaishi
May 2, 1989·European Journal of Pharmacology·R NakovC Allgaier

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