Bound to activate: conformational consequences of cyclin binding to CDK2

Structure
E Radzio-AndzelmS S Taylor

Abstract

The cyclin-dependent kinases (CDKs) are among the most highly regulated enzymes in the protein-kinase family. The crystal structures of cyclin A and the CDK2-cyclin A complex spectacularly reveal the atomic basis for regulation of these enzymes and provide a template for understanding the function and regulation of other members of the CDK family.

References

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Citations

Dec 1, 1996·Current Opinion in Cell Biology·D O Morgan
May 24, 2016·Scientific Reports·Soumya Lipsa Rath, Sanjib Senapati
Feb 16, 2010·Journal of Molecular Graphics & Modelling·Nahren Manuel MascarenhasNanda Ghoshal
Jun 21, 2014·Biochemistry·Soumya Lipsa Rath, Sanjib Senapati
Jan 26, 2005·The Journal of Biological Chemistry·Naoko Yoshizawa-SugataHisao Masai
Jun 13, 2001·The Journal of Biological Chemistry·K OginoH Masai
Apr 15, 2020·ACS Chemical Neuroscience·Annamarie B AllnuttVenkata Mahidhar Yenugonda
Dec 26, 2001·Chemical Reviews·D A JohnsonS S Taylor

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