Boundary-activated dissociation of peptide ions in a quadrupole ion trap

Analytical Chemistry
R W Vachet, G L Glish

Abstract

Boundary-activated dissociation (BAD) of peptides has been investigated as an alternative to the use of resonant excitation to effect collision-induced dissociation in the quadrupole ion trap. BAD's nonresonant excitation mechanism overcomes a major drawback in resonant excitation, namely, the variation of the resonant excitation frequency as a function of ion space charging. As with resonant excitation, the pulsed introduction of heavy gases (argon, xenon) extends the applicability of BAD when tandem mass spectrometry is performed on peptide ions. The presence of heavy gases during ion activation allows greater internal energy deposition and also enables BAD to be performed at much lower trapping field strengths (lower q values) than previously reported for this technique. This extends the mass range over which product ions can be collected.

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Citations

Aug 11, 2007·Analytical and Bioanalytical Chemistry·Chien-Wen HungWolf D Lehmann
Feb 4, 2012·Journal of the American Society for Mass Spectrometry·Boone M Prentice, Scott A McLuckey
Jul 17, 2012·Journal of the American Society for Mass Spectrometry·Mircea Guna
Nov 3, 2004·Journal of the American Society for Mass Spectrometry·Aleksey V TolmachevRichard D Smith
Feb 15, 2003·Journal of the American Society for Mass Spectrometry·Dunmin Mao, D J Douglas
Jul 3, 2003·Journal of the American Society for Mass Spectrometry·J MurrellD E Goeringer
Jul 29, 1998·Journal of the American Society for Mass Spectrometry·R W Vachet, G L Glish
Jan 13, 2006·Methods in Enzymology·Anne H Payne, Gary L Glish
Nov 4, 2016·Rapid Communications in Mass Spectrometry : RCM·Dalton T Snyder, R Graham Cooks
Jun 19, 2007·Analytical Chemistry·Olivier L CollinGlen P Jackson
Nov 20, 2001·Chemical Reviews·S A McLuckey, J M Wells

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