Boundary coding in the rat subiculum

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Sarah StewartColin Lever

Abstract

The spatial mapping function of the hippocampal formation is likely derived from two sets of information: one based on the external environment and the other based on self-motion. Here, we further characterize 'boundary vector cells' (BVCs) in the rat subiculum, which code space relative to one type of cue in the external environment: boundaries. We find that the majority of cells with fields near the perimeter of a walled environment exhibit an additional firing field when an upright barrier is inserted into the walled environment in a manner predicted by the BVC model. We use this property of field repetition as a heuristic measure to define BVCs, and characterize their spatial and temporal properties. In further tests, we find that subicular BVCs typically treat drop edges similarly to walls, including exhibiting field repetition when additional drop-type boundaries are added to the testing environment. In other words, BVCs treat both kinds of edge as environmental boundaries, despite their dissimilar sensory properties. Finally, we also report the existence of 'boundary-off cells', a new class of boundary-coding cells. These cells fire everywhere except where a given BVC might fire.

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Citations

Mar 10, 2016·Frontiers in Psychology·Guy CheronBernard Dan
Jun 13, 2015·Physiology & Behavior·Simone Cristina Motta, Newton Sabino Canteras
May 18, 2016·Neuropsychologia·Katrina Ferrara, Soojin Park
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Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Julija KrupicJohn O'Keefe
Aug 9, 2020·Nature Reviews. Neuroscience·Andrej Bicanski, Neil Burgess
Mar 1, 2019·Scientific Reports·Pawel MatulewiczShane M O'Mara
Oct 23, 2018·ELife·Alexandra T KeinathVijay Balasubramanian
Oct 17, 2017·Brain Structure & Function·Uwe MayerSang Ah Lee
Jan 20, 2021·Cell Research·Xiaoyang Long, Sheng-Jia Zhang
Apr 18, 2020·Current Biology : CB·Jacob M OlsonDouglas A Nitz
May 27, 2021·Cell Reports·Debora LedergerberEdvard I Moser

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