Bovine alveolar macrophage neurokinin-1 and response to substance P

Veterinary Immunology and Immunopathology
Donna P RogersDerek A Mosier

Abstract

In this study bovine alveolar macrophage neurokinin-1 (NK-1) and the in vitro response to substance P (SP) exposure were investigated. Bovine alveolar macrophage membrane extracts separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotted using anti-NK-1 antiserum demonstrated the presence of an approximately 60kDa band. Phagocytosis of fluorescent bioparticles by SP-exposed macrophages was 39% greater than that of non-exposed macrophages (P=0.0089). Likewise, there was 28% greater TNF production by macrophages following SP exposure compared to non-exposed controls (P=0.116). These results suggest that bovine alveolar macrophages respond to SP at least in part by enhancing phagocytosis and TNF production.

References

Jan 1, 1990·Annals of the New York Academy of Sciences·J P McGillisD G Payan
Feb 1, 1990·The American Review of Respiratory Disease·Y Sibille, H Y Reynolds
Jan 1, 1989·Annual Review of Medicine·D G Payan
Jun 15, 1989·Biochemical and Biophysical Research Communications·A PerianinB Malfroy
Aug 1, 1989·Veterinary Immunology and Immunopathology·D A MosierK D Clinkenbeard
Dec 29, 1995·Annals of the New York Academy of Sciences·C Chancellor-FreelandP H Black
Jul 9, 1998·Journal of Neuroimmunology·J P LaiW Z Ho
Sep 11, 1999·FEMS Microbiology Letters·T C AmbagalaS Srikumaran
Aug 10, 2000·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Y NishiJ Yamada
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·H P KuoL C Lu
Mar 10, 2001·Respiration Physiology·P J Barnes
Dec 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Branka GruborMark R Ackermann

❮ Previous
Next ❯

Citations

Apr 10, 2010·Veterinary Immunology and Immunopathology·Anja SipkaHans-Joachim Schuberth
Jan 30, 2008·Scandinavian Journal of Immunology·M Verdrengh, A Tarkowski
Nov 14, 2012·British Journal of Pharmacology·Jennifer Victoria Bodkin, Elizabeth Soares Fernandes
Mar 10, 2015·Veterinary Immunology and Immunopathology·E M AbdelfattahS D Eicher
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth S FernandesSusan D Brain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.