Bovine and murine tissue expression of insulin like growth factor-I

Gene
A M OberbauerJ F Medrano

Abstract

The genomic architecture and expression of the Igf-1 gene are complex yielding multiple IGF-I transcript isoforms with putative functional contributions to growth and metabolism. Using RNA-seq on different tissues, physiological states, and species, the breadth of transcripts expressed was determined. Tissues from pre- and post-pubertal heifers and mature mice were collected and the transcript isoforms characterized. Three different IGF-I isoforms were detected in heifers with Class 1 transcripts most abundantly expressed. The pituitary reduced IGF-I expression post-pubertally whereas the uterus increased expression. Murine IGF-I transcript expression was more diverse utilizing multiple exons, start sites, and 3'UTRs. The RNA-seq methodology to characterize expression profiles permits assessment of the transcript isoforms yielding insight into functional roles of each transcript.

References

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Citations

Mar 17, 2015·Journal of Animal Science and Biotechnology·Anita M Oberbauer
Jun 19, 2019·Animal Reproduction Science·Trish BergerHeidi Kucera

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